黄连解毒汤联合葛根素对老年2型糖尿病患者糖脂、血管内皮功能及炎症因子水平的影响

Effects of Huanglian Jiedu Decoction Combined with Puerarin on the Levels of Glucose and Lipid,Vascular Endothelial Function and Inflammatory Factors in Elderly Patients with Type 2 Diabetes Mellitus

目的探讨黄连解毒汤联合葛根素对老年2型糖尿病(T2DM)患者糖脂、血管内皮功能及炎症因子水平的影响。方法选取2020年2月—2023年2月铜川市耀州区孙思邈中医院收治的118例老年T2DM患者作为研究对象,根据随机数表法将其分为对照组和观察组,各59例。在常规治疗基础上,对照组给予黄连解毒汤治疗,观察组给予黄连解毒汤联合葛根素治疗。比较两组治疗前后血糖、血脂、炎症因子、血管内皮功能等实验室指标。结果治疗后,两组FPG、2 hPG、HbA1c水平均低于治疗前,且观察组2 hPG、HbA1c低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组TG、LDL-C水平均低于治疗前,差异有统计学意义(P<0.05),组间血脂水平比较,差异无统计学意义(P>0.05)。治疗后,两组TNF-α、IL-6、hs-CRP水平均低于治疗前,且观察组低于观察组,差异有统计学意义(P<0.05)。治疗后,观察组NO水平高于治疗前,ET-1水平低于治疗前,且观察组NO水平较对照组高,差异有统计学意义(P<0.05)。结论黄连解毒汤联合葛根素在降糖、抑炎及改善内皮功能方面具有更强效力,可作为血糖控制不佳的老年T2DM患者的辅助用药。

Objective To investigate the effects of Huanglian Jiedu Decoction(HLJDD)combined with puerarin on glucose and lipid,vascular endothelial function and inflammatory factors in elderly patients with type 2 diabetes(T2DM).Methods A total of 118 elderly T2DM patients admitted to Sun Simmiao Hospital in Yaozhou District of Tongchuan City from February 2020 to February 2023 were randomly divided into two groups.On the basis of conventional treatment,59 cases in the reference group were treated with Huanglian Jiedu decoction,59 cases in the combination group were treated with Huanglian Jiedu decoction combined with puerarin.Blood glucose,blood lipids,inflammatory factors,vascular endothelial function and other laboratory indicators were measured before and after treatment.Results After treatment,the levels of FPG,2hPG and HbA1c in the two groups were lower than before treatment(P<0.05),and the 2hPG and HbA1c in the combination group were lower than those in the reference group(P<0.05).After treatment,the levels of TG and LDL-C in combination group were lower than before treatment(P<0.05),but there was no difference in blood lipid levels between groups(P>0.05).After treatment,the levels of TNF-α,IL-6 and hs-CRP in 2 groups were lower than before treatment,and lower in combination group(P<0.05).After treatment,the level of NO in the combination group was higher than before treatment,and the level of ET-1 was lower than before treatment(P<0.05),and the level of NO in the combination group was higher than that in the reference group(P<0.05).Conclusion Huanglian Jiedu Tang combined with puerarin has stronger efficacy in lowering blood sugar,inhibiting inflammation,and improving endothelial function,and can be used as an auxiliary medication for elderly T2DM patients with poor blood sugar control.