CD56、SYN的表达与非小细胞肺癌及病理特征的相关性分析

Correlation analysis of CD56 and SYN expression with non-small cell lung cancer and its pathological features

目的:探讨非小细胞肺癌(Non-small cell lung cancer,NSCLC)组织中CD56、突触素(Synapsin,SYN)表达与临床病理特征的相关性。方法:选取2019年1月至2022年12月于本院就诊的NSCLC患者50例作为研究对象。观察癌组织和癌旁组织的CD56、SYN表达情况。分析比较不同病理特征NSCLC患者癌组织中CD56、SYN表达情况。分析癌组织中CD56、SYN表达与病理特征相关性。结果:NSCLC癌组织中CD56阳性表达率明显高于癌旁组织、SYN的阴性表达率明显高于癌旁组织(P<0.05)。不同转移情况、肿瘤分期的癌组织中CD56、SYN表达情况对比有差异(P<0.05)。NSCLC癌组织中的CD56表达与转移情况、肿瘤分期呈正相关关系(r>0,P<0.05),SYN阳性表达情况与转移情况、肿瘤分期呈负相关关系(r<0,P<0.05)。结论:NSCLC癌组织中CD56多呈阳性表达,SYN多呈阴性表达,CD56阳性表达、SYN阴性表达或可提示肿瘤已发生转移、或已发展至中晚期。

Objective:To investigate the correlation between the expression of CD56 and synapse(SYN)and clinicopathological features in non-small cell lung cancer(NSCLC).Methods:Fifty patients with NSCLC treated in our hospital from January 2019 to December 2022 were selected as the study objects.The expression of CD56 and SYN in cancer tissue and adjacent tissue were observed.The expressions of CD56 and SYN in cancer tissues with different pathological features were analyzed and compared.The correlation between the expression of CD56 and SYN in cancer tissues and pathological features was analyzed.Results:The positive expression rate of CD56 and negative expression rate of SYN in NSCLC tissues were significantly higher than those in adjacent tissues(P<0.05).There were differences in the expression of CD56 and SYN in different metastases and tumor stages(P<0.05).The expression of CD56 in NSCLC tissues was positively correlated with metastasis and tumor stage(r>0,P<0.05),and the expression of SYN was negatively correlated with metastasis and tumor stage(r<0,P<0.05).Conclusion:CD56 is mostly positive and SYN is mostly negative in cancer tissues of NSCLC.The positive expression of CD56 and negative expression of SYN may indicate that the tumor has metastasized or has developed to the middle or late stages.