通脉降糖胶囊联合度拉糖肽治疗肥胖2型糖尿病的临床效果观察

Clinical observation of Tongmai Jiangtang capsule combined with Dulotide in treating obese type 2 diabetes mellitus

目的:探讨肥胖2型糖尿病采用通脉降糖胶囊联合度拉糖肽治疗的临床效果及安全性。方法:回顾性收集2022年1月至2023年9月期间本院收治的87例肥胖2型糖尿病患者的临床资料。根据不同治疗方法将患者分为对照组(度拉糖肽治疗,43例)和研究组(通脉降糖胶囊联合度拉糖肽治疗,44例)。分析比较两组的疗效、血糖相关指标(糖化血红蛋白、空腹血糖、餐后2 h血糖)、中医证候积分、血液流变学指标及不良事件发生情况。结果:治疗2 m后,研究组的治疗总有效率显著高于对照组(P<0.05)。研究组的糖化血红蛋白、空腹血糖、餐后2 h血糖显著低于对照组(P<0.05)。治疗后,两组的各项中医证候积分均显著降低,且研究组的各项中医证候积分均显著低于对照组(P<0.05)。研究组的各项血液流变学指标均显著优于对照组(P<0.05)。两组的不良反应发生率无明显差异(P>0.05)。结论:通脉降糖胶囊联合度拉糖肽治疗肥胖2型糖尿病,能提高临床疗效,控制血糖水平,改善患者中医证候情况,降低血黏度,改善微循环,且不增加不良反应。

Objective:To investigate the clinical effect and safety of Tongmai Jiangtang capsule combined with Dulotide in the treatment of obese type 2 diabetes mellitus.Methods:The clinical data of 87 obese patients with type 2 diabetes admitted to our hospital from January 2022 to September 2023 were retrospectively collected.According to different treatment methods,the patients were divided into control group(43 cases)and study group(Tongmai Jiangtang capsule combined with Dula glycopeptide treatment,44 cases).The efficacy,blood glucose related indexes(HBA1c,fasting blood glucose,2 hours postmeal blood glucose),TCM syndrome score,hemorheology indexes and adverse events of the two groups were analyzed and compared.Results:After 2 months of treatment,the total effective rate of the study group was significantly higher than that of the control group(P<0.05).The HBA1c,fasting blood glucose and 2 hours postprandial blood glucose of the study group were significantly lower than those of the control group(P<0.05).After treatment,the scores of TCM symptoms in both groups were significantly decreased,and the scores of TCM symptoms in the study group were significantly lower than those in the control group(P<0.05).The hemorheology indexes of the study group were significantly better than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Tongmai Jiangtang capsule combined with Dula glycopeptide in the treatment of obesity type 2 diabetes can improve clinical efficacy,control blood sugar level,improve TCM symptoms,reduce blood viscosity,improve microcirculation,and do not increase adverse reactions.