对伞花烃的来源、合成及生物活性研究与应用进展

Progress in the research and application of p-cymene in its source,synthesis,and biological activity

对伞花烃是一种富含生物活性的单萜烯,广泛存在于自然界多种植物中,具有结构稳定、易于合成等优点。本文综述了对伞花烃的来源与含量,列举了以甲苯、单环萜烯类、双环萜烯类等化合物为原料的化学合成途径,并总结了不同途径的优缺点;重点归纳了对伞花烃在预防糖尿病、镇痛、抗炎、抗氧化等方面的功效,还介绍了对伞花烃药代动力学、安全性评价及在食品、医药等领域的应用,最后提出了目前研究存在的不足与未来发展趋势,旨在为实现对伞花烃高效利用、促进其产业化发展提供参考。

P-cymene is a biologically active monoterpene,which is widely found in many plants in nature and has the advantages of stable structure and easy synthesis.This paper,we reviewed the sources and contents of p-cymene,listed the chemical synthesis routes of toluene,monocyclic terpenes and bicyclic terpenes as raw materials,and summarized the advantages and disadvantages of the different routes;we focused on the efficacy of p-cymene in the prevention of diabetes mellitus,analgesia,anti-inflammation,antioxidant.Furthermore,we also introduced p-cymene pharmacokinetics,safety evaluation,and its applications in the fields of food and medicine.Finally,we also put forward the shortcomings of the current research and the future development trend,aiming to achieve the efficient use of p-cymene,and promote their industrial development as a reference.