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红花在蒙药应用中的研究进展

Research Pogress of Saffron in the Aplication of Mongolian Mdicine
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摘要 目的:红花为菊科一年生草本植物红花(Carthamu stinctorius L.)的干燥花。作为传统的民族药材,具有很高的开发利用价值,本研究旨在为红花的现代研究提供科学依据,为其新药开发和质量评价提供理论支撑。方法:以“红花”“化学成分”“药理作用”“生物活性”“临床应用”“质量标准”等作为关键词,在中国知网、维普、万方、Pubmed等数据库进行相关检索,对其化学成分、药理作用、临床应用等进行归纳总结。结果:共检索到相关文献200余篇,其中有效文献90余篇。红花中的化学成分主要有黄酮类、生物碱、醌氏查耳酮类、炔类、亚精胺类成分和一些其他类别的化合物;具有抗氧、抗纤维化、保护血管内皮功能、抗凝血等药理作用。在蒙医临床中,红花主要被用于预防和治疗血热病、妇科病、肝病、清热解毒等。结论:当前对于红花的化学成分研究已相对全面,而其药理研究则主要围绕治疗冠心病、心绞痛等方面进行。在蒙医临床治疗中,红花通常与清热解毒类药物联合使用,但目前尚未出现关于其毒副作用的明确报道。 Objective:Saffron is the dried flower of Carthamus tinctorius L,an annual herb of Asteraceae family.As a traditional ethnic medicinal herb with high development and utilization value,this study aims to provide a scientific basis for the modern study of saffron and theoretical support for its new drug development and quality evaluation.Methods:Using keywords such as‘saffron’,‘chemical composition',‘pharmacological effect’,‘biological activity’,‘clinical application’and‘quality standards’,etc.,relevant searches were conducted on databases of CNKI,Wipo,Wanfang and Pubmed.The chemical composition.pharmacological effect and clinical application of saffron were summarized.Resluts:A total of more than 200 relevant literatures were searched,of which more than 90 were valid.It was found that the chemical constituents in saffron mainly contain flavonoids,alkaloids,quinone chalcones,alkynes,subarginine amines,and some other classes of compounds;they have antioxidant,antifibrotic,protection of endothelial function of the vasculature,anticoagulant and other pharmacological effects.In the clinic of Mongolian medicine,saffron is mainly used for the prevention and treatment of blood fever,gynaecological diseases,liver diseases,clearing heat and detoxification,etc.Conclusion:The current research on the chemical composition of saffron has been relatively comprehensive,while its pharmacological research mainly focuses on the treatment of coronary heart disease,angina pectoris and other aspects.In the clinical treatment of Mongolian medicine,safron is usually used in combination with heat-clearing and detoxification drugs,but there is no clear report on its toxic side effects.
作者 包秀芳 呼日乐巴根 戴丽丽 白文明 铁龙 清明 白其格其 陈美玲 莲花 Bao Xiufang;Hurilebagen;Dai Lili;Bai Wenming;Tie Long;Qing Ming;Baiqigeqi;Chen Meiling;Lian Hua(School of Mongolian Medicine,Inner Mongolia Medical University,Hohhot,010110;College of Pharmacy,Inner Mongolia Medical University,Hohhot 010110,China)
出处 《中国药事》 CAS 2024年第8期945-960,共16页 Chinese Pharmaceutical Affairs
基金 内蒙古自治区蒙医药协同创新中心科学研究项目(编号MYYXTYB2021010) 内蒙古医科大学2021年度大学生创新创业训练计划立项项目(编号2021101132012) 2023年度内蒙古医科大学中药学(蒙药学)“一流学科”研究生科研能力提升计划项目(编号MYX2023-R05) 2023内蒙古医科大学面上项目(编号YKD2023MS062)。
关键词 红花 化学成分 药理作用 综述 Carthamus tinctorius L chemical component pharmacologic effects review
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