我国青少年抑郁症患者非自杀性自伤行为危险因素Meta分析

Meta-analysis of Risk Factors of Non-suicidal Self-injury Behavior in Chinese Adolescents with Depression

目的:探讨我国青少年抑郁症患者非自杀性自伤(NSSI)行为的相关危险因素。方法:计算机检索PubMed、Web of Science、Cochrane Library、Embase、Psyinfo、万方、维普、中国知网、中国生物医学文献数据库,纳入有关我国青少年抑郁症患者NSSI危险因素的相关文献,检索时间为建库至2023年10月。由2名研究者独立筛选文献和提取数据,对纳入研究文献采用NOS量表或AHRQ量表进行质量评价,使用Rev Man5.4软件对数据进行Meta分析。结果:共纳入25项研究,总样本量为4310例。Meta分析结果显示,性别[OR=2.44,95%CI(1.50,3.94)]、焦虑[OR=1.06,95%CI(1.02,1.09)]、抑郁[OR=1.07,95%CI(1.02,1.12)]、冲动行为[OR=1.37,95%CI(1.17,1.43)]、自杀意念[OR=1.07,95%CI(1.04,1.10)]、消极应对[OR=2.09,95%CI(1.43,3.05)]、家庭功能适应性[OR=0.88,95%CI(0.81,0.92)]、不良生活事件[OR=1.56,95%CI(1.17,2.08)]、人际关系[OR=1.86,95%CI(1.58,2.18)]、学习压力[OR=2.23,95%CI(1.66,3.01)]、童年期虐待[OR=2.36,95%CI(1.39,4.03)]、情感虐待[OR=1.28,95%CI(1.12,1.47)]、情感忽视[OR=1.40,95%CI(1.12,1.76)]、支持利用度[OR=0.28,95%CI(0.13,0.62)]对青少年抑郁症患者NSSI影响,差异有统计学意义(P<0.05)。结论:我国青少年抑郁症患者发生NSSI的危险因素复杂多样,应建立医院、家庭、学校及社会联动干预方案,预防NSSI行为的发生。

OBJECTIVE To explore the risk factors of non-suicidal self-injury(NSSI)in adolescents with depression in China.METHODS PubMed,Web of Science,Embase,Cochrane Library,Psyinfo,Wanfang Data,VIP,CNKI and Sinomed,were searched by computer.Relevant articles on risk factors of NSSI in adolescents with depression in China were included.The search time was from the establishment of the database to October 2023.Two researchers independently screened the literature and extracted the da⁃ta.Newcastle-ottawa Scale(NOS)or AHRQ scale was used to evaluate the quality of the included studies.RevMan5.4 software was used for Meta-analysis.RESULTS A total of 25 studies were included,with a total sample size of 4310.The results of Meta-analy⁃sis showed that gender[OR=2.44,95%CI(1.50,3.94)],anxiety[OR=1.06,95%CI(1.02,1.09)],depression[OR=1.07,95%CI(1.02,1.12)],impulsive behavior[OR=1.37,95%CI(1.17,1.43)],suicidal ideation[OR=1.07,95%CI(1.04,1.10)],negative coping[OR=2.09,95%CI(1.43,3.05)],family functional adaptability[OR=0.88,95%CI(0.81,0.92)],adverse life events[OR=1.81,95%CI(1.38,2.38)],interpersonal relationships[OR=1.86,95%CI(1.58,2.18)],academic stress[OR=2.23,95%CI(1.66,3.01)],childhood abuse[OR=2.36,95%CI(1.39,4.03)],emotional abuse[OR=1.28,95%CI(1.12,1.47)],emotional neglect[OR=1.40,95%CI(1.12,1.76)],support utilization[OR=0.28,95%CI(0.13,0.62)]had a significant effect on NSSI in adolescent patients with depression(P<0.05).CONCLUSION The risk factors for NSSI in adolescents with depression in China are complex and diverse.It is necessary to es⁃tablish a hospital,family,school,and social linkage intervention program to prevent non-suicidal self-injury.