中药多糖防治肾损伤作用机制的研究进展

Research progress on the mechanism of traditional Chinese medicine polysaccharides in preventing and treating kidney injury

中药多糖是从中草药中提取的一类活性多糖,其中许多具有特殊的生物活性。现代研究发现,从植物、动物、藻类等中提取的多糖成分有改善肾脏损伤的重要作用。目前肾损伤的治疗以药物治疗为主,对于中药多糖治疗肾损伤的研究报道较少。本文从肾损伤的类型出发,阐述了中药多糖对糖尿病肾病、肾炎、肾结石、高血压诱导的肾损伤、化学毒物诱导的肾损伤和药物诱导的肾损伤的改善作用及机制,展望了中药多糖在肾损伤领域的发展前景,以期为中药多糖的进一步研究提供参考。

Traditional Chinese medicine(TCM)polysaccharides are active polysaccharides extracted from Chinese herbal medicines,many of which exhibit specific biological activities.Modern research has revealed that polysaccharide components extracted from plants,animals,and algae have a significant role in improving kidney injury.Currently,drug therapy is the primary treatment for kidney injury,with few reports on the use of TCM polysaccharides.This review explores the therapeutic effects and mechanisms of TCM polysaccharides on diabetic nephropathy,nephritis,kidney stones,hypertension-induced kidney injury,chemical toxin-induced kidney injury,and drug-induced kidney injury.Additionally,it discusses the prospects for the development of TCM polysaccharides in this field to provide a reference for further research.