不同剂量间苯三酚联合黄体酮治疗妊娠早期先兆流产的临床疗效

Clinical efficacy of different doses of triphenylphenol combined with progesterone in the treatment of threatened miscarriage in early pregnancy

目的探讨不同剂量间苯三酚联合黄体酮治疗妊娠早期先兆流产的临床疗效。方法选择浙江省杭州市淳安县第一人民医院2021年1月~2022年12月妊娠早期先兆流产孕妇367例,按照随机数字表法分为黄体酮组122例(单纯使用黄体酮),观察A组122例(使用黄体酮联合间苯三酚40mg/次,1次/d),观察B组123例(使用黄体酮联合间苯三酚40mg/次,2次/d)。比较三组临床症状改善情况[临床症状(阴道流血、腹痛或宫缩缓解)消失时间,临床症状复发例数和难免流产例数]、临床疗效及不良反应。结果在临床症状改善方面,黄体酮组、观察A组、观察B组先兆流产临床症状消失时间逐渐缩短(P<0.01),临床症状复发率观察A组低于黄体酮组(P<0.05),观察B组低于观察A组(P<0.05),三组难免流产发生率差异无统计学意义(P>0.05)。在临床疗效方面,观察A组和观察B组总有效率均高于黄体酮组(P<0.05),观察A组与观察B组之间差异无统计学意义(P>0.05)。在药物安全性方面,三组皮疹、头晕、头痛及肝功异常的发生率差异无统计学意义(P>0.05)。结论间苯三酚联合黄体酮可以提高妊娠早期先兆流产的治疗效果,40mg/次,2次/d的间苯三酚的应用方案更有助于快速改善临床症状。

Objective To investigate the clinical efficacy of different doses of triphenylphenol combined with progesterone in the treatment of threatened miscarriage in early pregnancy.Method 367 pregnant women with threatened miscarriage in early pregnancy from January 2021 to December 2022 were selected from the First People's Hospital of Chun'an County,Hangzhou City,Zhejiang Province.They were randomly divided into a progesterone group of 122 cases(using progesterone alone),an observation group of 122 cases(using progesterone combined with phloroglucinol 40mg/time,once a day),and an observation group of 123 cases(using progesterone combined with phloroglucinol 40mg/time,twice a day).Compare the improvement of clinical symptoms(disappearance time of clinical symptoms(vaginal bleeding,abdominal pain or uterine contractions),number of clinical symptom recurrence cases and inevitable miscarriage cases),clinical efficacy and adverse reactions among three groups.Results In terms of clinical symptom improvement,the disappearance time of clinical symptoms of threatened miscarriage gradually shortened in the progesterone group,observation group A,and observation group B(P<0.01).The recurrence rate of clinical symptoms was lower in observation group A than in the progesterone group(P<0.05),and lower in observation group B than in observation group A(P<0.05).There was no statistically significant difference in the incidence of inevitable miscarriage among the three groups(P>0.05).In terms of clinical efficacy,the total effective rate of observation group A and observation group B was significantly higher than that of progesterone group(P<0.05),and there was no statistically significant difference between observation group A and observation group B(P>0.05).In terms of drug safety,there was no statistically significant difference in the incidence of rash,dizziness,headache,and abnormal liver function among the three groups(P>0.05).Conclusion The combination of triphenylphenol and progesterone can improve the treatment effect of threatened miscarriage in early pregnancy.The application regimen of 4Omg/time,twice a day of triphenylphenol is more helpful in rapidly improving clinical symptoms.