基于中医体质学说探讨化痰祛湿代茶饮联合西药治疗代谢综合征临床疗效

Clinical Effect of Eliminating Phlegm and Dispelling Dampness Substitute Tea Combined with Western Medicine in Treatment of Metabolic Syndrome Based on Traditional Chinese Medicine Constitution Theory

目的:以体质学说为理论基础,探讨化痰祛湿代茶饮联合西医治疗代谢综合征的临床疗效。方法:将99例痰湿质代谢综合征患者按随机数字表法分为对照组、代茶饮组、中西医组,每组各33例。对照组进行生活方式干预,代茶饮组在对照组的基础上加化痰祛湿代茶饮,中西医组在对照组的基础上给予化痰祛湿代茶饮和西医对症治疗,通过12周的干预,观察三组患者的代谢指标[体质量、体质量指数(BMI)、腰围、血压、血糖、血脂]、体质及生活质量的变化情况,评估临床疗效。结果:①代谢指标比较,干预后三组患者体质量、BMI、腰围、血压、血糖、血脂(高密度脂蛋白胆固醇除外)均较干预前下降(P<0.05),且三组间比较,差异具有统计学意义(P<0.05);②体质得分比较,干预后三组患者的体质得分均较干预前下降(P<0.01),且三组间比较,差异具有统计学意义(P<0.01);③生活质量得分比较,干预后三组患者的生活质量得分除社会功能外,其他7个维度得分均较干预前上升(P<0.05),三组间比较,生理功能、生理职能、情感职能、活力、精神健康及总体健康得分差异具有统计学意义(P<0.05);④临床疗效比较,中西医组(93.55%)优于代茶饮组(87.50%)和对照组(68.75%),差异有统计学意义(P<0.05)。结论:化痰祛湿代茶饮能够改善代谢综合征的相关临床症状,调节患者的痰湿体质,使其趋于平和,提高生活质量。

Objective:To explore the clinical effect of eliminating phlegm and dispelling dampness substitute tea combined with western medicine in the treatment of metabolic syndrome based on traditional Chinese medicine constitution theory.Methods:A total of 99 patients with phlegm-dampness metabolic syndrome were divided into the control group,substitute tea drinking group and traditional Chinese and western medicine group according to random number table method,with 33 cases in each group.The control group received lifestyle intervention,the substitute tea drinking group was supplemented with eliminating phlegm and dispelling dampness substitute tea on the basis of the treatment of the control group,and the traditional Chinese and western medicine group was supplemented with eliminating phlegm and dispelling dampness substitute tea and western symptomatic treatment on the basis of the treatment of the control group.After 12 weeks of intervention,the changes of metabolic indexes[body mass,body mass index(BMI),waist circumference,blood pressure,blood glucose,blood lipid],constitution and quality of life of patients in the three groups were observed,and the clinical efficacy was evaluated.Results:(1)Comparison of metabolic indexes showed that body mass,BMI,waist circumference,blood pressure,blood glucose and blood lipids(except high density lipoprotein cholesterol)in the three groups were all decreased after intervention(P<0.05),and the differences among the three groups were statistically significant(P<0.05).(2)Compared with those before intervention,the physical scores of the three groups decreased after intervention(P<0.01),and the difference among the three groups was statistically significant(P<0.01).(3)Quality of life scores of the three groups increased compared with that before intervention in seven dimensions except social functioning(P<0.05).The scores of physical functioning,role-physical,role emotional,vitality,mental health and general health were significantly different among the three groups,and the differences were statistically significant(P<0.05).(4)Comparison of clinical efficacy showed that traditional Chinese and western medicine group(93.55%)was better than substitute tea drinkink group(87.50%)and the control group(68.75%),the difference was statistically significant(P<0.05).Conclusion:Eliminating phlegm and dispelling dampness substitute tea can relieve the related clinical symptoms of metabolic syndrome,regulate the phlegm-dampness constitution of patients,make them harmonize,and thus improve the quality of life of patients.