线粒体稳态调控帕金森病机制及中医药干预作用研究进展

Research Progress on Mechanism of Mitochondrial Homeostasis in Regulating Parkinson’s Disease and Intervention Effect of Traditional Chinese Medicine

帕金森病(PD)是中老年三大致残疾病之一,是由多种因素共同参与造成大脑多巴胺能神经元变性死亡导致的。大量证据表明,线粒体是细胞能量代谢的核心环节,线粒体稳态失衡可能在PD发生、进展中起到重要作用。鉴于此,本文基于相关研究,阐述了线粒体的基本结构及功能,从线粒体动力学、线粒体自噬、线粒体Ca2+紊乱、线粒体氧化应激几个方面,分析了线粒体稳态调节在PD发病机制及治疗中的作用,概述中药及其提取物通过保护线粒体功能,维持线粒体稳态,延缓PD进展的研究,以期为今后临床治疗PD提供新思路。参考文献59篇。

Parkinson’s disease(PD)is one of the three major disability diseases in the middle-aged and elderly,it is caused by multiple factors involved in the degeneration and death of dopaminergic neurons in the brain.A large amount of evidence shows that mitochondria are the core links of cellular energy metabolism,and mitochondrial homeostasis may play an important role in the occurrence and progression of PD.In view of this,based on related studies,this paper expounds the basic structure and function of mitochondria,and analyzes the role of mitochondrial homeostasis regulation in the pathogenesis and treatment of PD from the perspectives of mitochondrial dynamics,mitochondrial autophagy,mitochondrial Ca2+disorder and mitochondrial oxidative stress,and summarizes the role of traditional Chinese medicine and its extracts in protecting mitochondrial function and maintaining mitochondrial homeostasis,and delaying the progression of PD,in order to provide new ideas for the future clinical treatment of PD.There are 59 references.