中医药调节Th1/Th2平衡治疗非哺乳期乳腺炎研究进展

Research progress of traditional Chinese medicine regulating Th1/Th2 balance for non⁃puerperal mastitis

非哺乳期乳腺炎(NPM)病程长,易反复发作,其发生、发展与机体免疫功能紊乱、辅助性T细胞(Th)1/Th2失衡有关。从免疫炎症角度探讨中医药治疗NPM的作用机制,综述中医药对NPM患者Th1/Th2平衡的调节作用。中医药可以通过调节Th1、Th2型细胞因子的分泌,抑制白细胞介素-6(IL-6)/蛋白酪氨酸激酶2(JAK2)/信号转导及转录激活因子3(STAT3)、Toll样受体4(TLR4)/核因子-κB(NF-κB)等信号通路的激活,纠正CD4+T细胞亚群的分化失衡等途径,恢复NPM患者的免疫稳态,从而发挥治疗作用。

Non-puerperal mastitis(NPM)is characterized by a prolonged course and frequent recurrences,and its development and progression are associated with immune dysfunction and an imbalance of helper T cells(Th)1/Th2.This review discusses the mechanisms of traditional Chinese medicine(TCM)in treating NPM from the perspective of immune inflammation,summarizing the effects of TCM on regulating the Th1/Th2 balance in patients with NPM.TCM may restore the immune homeostasis of NPM patients by regulating the secretion of Th1 and Th2 cytokines,inhibiting the activation of interleukin-6(IL-6)/Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3),Toll-like receptor 4(TLR4)/nuclear factor-kappa B(NF-κB)signaling pathways,and correcting the differentiation imbalance of CD4+T cell subgroups,thereby exerting therapeutic effects.