炎症性肠病中肠道微生物与细胞因子的相互作用研究进展

Research advance on the interaction between gut microbes and cytokines in inflammatory bowel disease

肠道微生物和宿主免疫系统之间相互作用的紊乱会引发慢性炎症,例如炎症性肠病(IBD),包括克罗恩病(CD)和溃疡性结肠炎(UC)。研究表明IBD宿主肠道微生物可以直接或间接地影响免疫系统稳态,而促炎和抗炎细胞因子之间的平衡又能参与维持健康的微生物群落并加强肠上皮屏障功能。IBD中肠道微生物与白细胞介素10(IL-10)、IL-17、IL-18、肿瘤坏死因子α(TNF-α)的相互作用对于了解IBD的发病机制具有特别重要的意义。

Dysregulation of interaction between the gut microbiota and the host immune system leads to the development of chronic inflammation,such as inflammatory bowel disease(IBD),including Crohn's disease(CD)and ulcerative colitis(UC).Numerous studies have shown that the host-microbiota of IBD can directly or indirectly affect the homeostasis of the immune system.Furthermore,the balance between pro-inflammatory and anti-inflammatory cytokines involves in maintaining a healthy microbiota community and enhances epithelial barrier functions.Understanding the interactions between gut microbiota and cytokines(IL-10、IL-17、IL-18、TNF-α)provides crucial insights into the pathogenesis of inflammatory bowel disease.