少阴益气通脉汤治疗糖尿病周围神经病变患者的临床疗效

Clinical Efficacy of Shaoyin Yiqi Tongmai Decoction in Treating Patients with Diabetic Peripheral Neuropathy

目的探究糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)治疗中应用少阴益气通脉汤的效果。方法选取2023年6月—2024年1月延边朝鲜族自治州朝医医院内分泌科就诊的72例DPN患者作为研究对象,按照治疗方法不同分为对照组(常规控糖治疗措施与甲钴胺片、依帕司他联用治疗)、治疗组(对照组基础上加入少阴益气通脉汤治疗),各36例,比较两组治疗前及治疗4周后的多伦多临床评分系统(To-ronto Clinical Scoring System,TCSS)评分、糖代谢指标(空腹血糖、糖化血红蛋白)、四肢电流感觉阈值、证候积分(四肢不温、肌肤甲错、筋骨疼痛、麻木不仁、步履艰难、脉濡缓或脉弦细涩)。结果治疗4周后,治疗组TCSS评分、糖代谢指标、四肢电流感觉阈值均优于对照组,差异有统计学意义(P均<0.05)。治疗4周后,治疗组证候积分低于对照组,差异有统计学意义(P<0.05)。结论DPN患者治疗中加入少阴益气通脉汤,可改善糖代谢指标、四肢电流感觉阈值及证候积分。

Objective To investigate the effect of the application of Shaoyin Yiqi Tongmai Decoction in the treatment of diabetic peripheral neuropathy(DPN).Methods From June 2023 to January 2024,a total of 72 DPN patients who were admitted to the department of Endocrinology of Yanbian Korean Autonomous Prefecture Korean Medical Hospi-tal were selected as the research objects.According to different treatment methods,they were divided into control group(conventional glucose control treatment measures combined with methylcobalamin tablets and epalrestat treat-ment)and treatment group(Shaoyin Yiqi Tongmai decoction treatment on the basis of the control group),36 cases in each group.The Toronto Clinical Scoring System(TCSS)score,glucose metabolism index(fasting blood glucose,gly-cated hemoglobin A1c),limb current sensory threshold,syndrome score(limbs are not warm,scaly skin,bones and muscles are painful,Numb,walking is difficult,pulse is slow or pulse string is fine and astringent)were compared be-tween the two groups before and after 4 weeks of treatment.Results After 4 weeks of treatment,the TCSS score,glu-cose metabolism index and limb current sensation thresholds in the treatment group were better than those in the con-trol group,and the differences were statistically significant(all P<0.05).After 4 weeks of treatment,the syndrome score of the treatment group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The addition of Shaoyin Yiqi Tongmai decoction in the treatment of DPN patients can improve the glucose metabolism index,limb current sensory thresholds and symptom score.