低频度血液灌流联合血液透析治疗对糖尿病慢性肾功能衰竭患者肾功能及血糖指标的影响

Effects of Low Frequency Hemoperfusion Combined with Hemodialysis on Renal Function and Blood Glucose in Patients with Diabetes Mellitus and Chronic Renal Failure

目的分析对糖尿病慢性肾功能衰竭患者同时实施低频度血液灌流、血液透析治疗的效果。方法回顾性选取2023年3月—2024年3月泉州市第一医院收治的94例糖尿病慢性肾功能衰竭患者的临床资料,按照治疗方法的不同分为对照组(47例,单纯血液透析治疗)、观察组(47例,低频度血液灌流联合血液透析治疗)。比较两组患者血糖指标(空腹血糖、餐后2 h血糖、糖化血红蛋白)、胰岛功能(胰岛素抵抗指数、胰岛β细胞功能指数)、肾功能指标(24 h尿蛋白定量、血肌酐、尿素氮)、不良反应(营养不良、皮肤瘙痒、恶心呕吐)发生情况。结果观察组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于对照组,差异有统计学意义(P均<0.05)。观察组胰岛功能低于对照组,差异有统计学意义(P均<0.05)。观察组各项肾功能指标均优于对照组,差异有统计学意义(P均<0.05)。对照组不良反应总发生率高于观察组,差异有统计学意义(P<0.05)。结论糖尿病慢性肾功能衰竭患者采取低频度血液灌流联合血液透析治疗具备一定优势,能够有效改善患者的血糖水平和肾功能。

Objective To analyze the efficacy of low frequency hemoperfusion combined with hemodialysis in patients with diabetes mellitus and chronic renal failure.Methods The clinical data of 94 patients of diabetes mellitus and chronic renal failure admitted to Quanzhou First Hospital from March 2023 to March 2024 were retrospectively se-lected.According to the different treatment methods,they were divided into control group(47 cases,treated with simple hemodialysis)and observation group(47 cases,treated with low frequency hemoperfusion combined with hemo-dialysis).The blood glucose indexes(fasting plasma glucose,2-hour postprandial plasma glucose,glycated hemoglo-bin A1c),islet function indexes(insulin resistance index,isletβcell function index),renal function indexes(24 h urine protein quantitative,serum creatinine,urea nitrogen),and adverse reactions(malnutrition,skin pruritus,nausea and vomiting)were compared between the two groups.Results The levels of fasting plasma glucose,2-hour postpran-dial plasma glucose and glycated hemoglobin A1c in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The islet function of the observation group was better than that of the control group,and the differences were statistically significant(both P<0.05).The renal function in-dexes of the observation group were better than those of the control group,and the differences were statistically signifi-cant(all P<0.05).The total incidence of adverse reactions in the control group was higher than that in the observation group,and the difference was statistically significant(P<0.05).Conclusion The combination of low frequency hemo-perfusion and hemodialysis has good advantages for diabetic patients with chronic renal failure,which can effectively improve the blood glucose level and renal function of patients.