津力达颗粒结合门冬胰岛素对妊娠期糖尿病孕妇糖代谢及不良结局的影响

Effect of Jinlida Granule and Aspartate Insulin on Glucose Metabolism and Adverse Outcome in Pregnant Women with Gestational Diabetes Mel⁃litus

目的探究津力达颗粒结合门冬胰岛素对妊娠期糖尿病孕妇糖代谢及不良结局的影响。方法选取2022年2月—2023年10月招远市妇幼保健服务中心妇产科收治的86例妊娠期糖尿病孕妇为研究对象,根据不同治疗方案分为两组,各43例,对照组采取门冬胰岛素治疗,观察组采取门冬胰岛素、津力达颗粒联合治疗,对比两组治疗总有效率、不良妊娠结局(产后出血、早产、巨大儿、胎儿窘迫)发生情况、低血糖发生率、糖代谢水平(空腹血糖、餐后2 h血糖、糖化血红蛋白)。结果观察组治疗总有效率为95.35%(41/43),高于对照组的81.40%(35/43),差异有统计学意义(χ^(2)=4.074,P<0.05)。观察组糖代谢相关指标改善程度优于对照组,差异有统计学意义(P均<0.05)。观察组不良妊娠结局发生率低于对照组,低血糖发生率低于对照组,但差异无统计学意义(P均>0.05)。结论津力达颗粒、门冬胰岛素的联合效果更优,且安全性高,有助于调节患者糖代谢水平,优化母婴结局。

Objective To explore the effect of Jinlida Granule combined with aspartate insulin on glucose metabolism and adverse outcomes in pregnant women with gestational diabetes mellitus.Methods A total of 86 pregnant women with gestational diabetes mellitus admitted to Department of Obstetrics and Gynecology of Zhaoyuan Maternal and Child Health Service Center from February 2022 to October 2023 were selected as the research objects.According to the different treatment method,they were divided into two groups,43 cases in each group.The control group was treated with aspartate insulin,and the observation group was treated with aspartate insulin and Jinlida Granules.The total effective rate,adverse pregnancy outcome(postpartum hemorrhage,premature delivery,macrosomia,fetal dis-tress),incidence of hypoglycemia,glucose metabolism level(fasting plasma glucose,2-hour postprandial plasma glu-cose and glycated hemoglobin A1c)of the two groups were compared.Results The total effective rate of the observa-tion group was 95.35%(41/43),which was higher than 81.40%(35/43)of the control group,and the difference was sta-tistically significant(χ^(2)=4.074,P<0.05).The improvement of glucose metabolism related indexes in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).The in-cidence of adverse outcomes pregnancy in the observation group was lower than that in the control group,and the inci-dence of hypoglycemia was lower than that in the control group,but the differences were not statistically significant(both P>0.05).Conclusion The combined effect of Jinlida Granules and aspartate insulin is better,and the safety is high.It is helpful to regulate the level of glucose metabolism and optimize the outcome of mother and infant.