利拉鲁肽联合二甲双胍缓释片在脑梗死合并糖尿病患者中的效果及对血液流变学的影响研究

Effect of Liraglutide Combined with Metformin Sustained-release Tablets in Patients with Cerebral Infarction Complicated with Diabetes Mellitus and Its Influence on Hemorheology

目的分析在脑梗死合并糖尿病患者中应用利拉鲁肽联合二甲双胍缓释片的治疗效果及对血液流变学的影响。方法选择2023年1—12月昌乐县人民医院收治的88例脑梗死合并糖尿病患者为研究对象,按照治疗方案不同,分为对照组(在脑梗死治疗的基础上给予二甲双胍缓释片治疗)和观察组(在对照组基础上联合利拉鲁肽治疗),各44例,比较两组的治疗总有效率、血糖(空腹血糖、餐后2 h血糖)水平与血液流变学指标(D-二聚体、纤维蛋白原)。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组血糖水平低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组的纤维蛋白原与D-二聚体水平均低于对照组,差异有统计学意义(P均<0.05)。结论利拉鲁肽联合二甲双胍缓释片对糖尿病合并脑梗死患者具有较好的治疗效果,同时具有改善血液流变学的作用。但在临床上,还需要针对患者的个体差异,对其进行定期监测,才能保证患者取得较好的疗效。

Objective To analyze the effect of liraglutide combined with metformin sustained release tablets on hemorheology in patients with cerebral infarction and diabetes mellitus.Methods A total of 88 patients with cerebral infarction and diabetes mellitus admitted to Changle County People's Hospital from January to December 2023 were selected as the research objects.According to different treatment schemes,they were divided into control group(treated with metformin sustained-release tablets on the basis of cerebral infarction treatment)and observation group(treated with liraglutide on the basis of control group),with 44 cases in each group.The total effective rate blood glu-cose(fasting plasma glucose,2 hour postprandial plasma glucose)level and hemorheology indexes(fibrinogen and D-dimer)of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the blood glucose levels of the observation group were lower than those of the control group,and the differences were sta-tistically significant(both P<0.05).After treatment,the levels of fibrinogen and D-dimer in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).Conclusion Lira-glutide combined with metformin sustained release tablets has a good effect on diabetes patients with cerebral infarc-tion,and can improve hemorheology.However,in clinical practice,it is also necessary to regularly monitor the indi-vidual differences of patients in order to ensure that patients achieve better curative effects.