腹腔镜胆囊切除术对胆结石患者预后的影响

The Impact of Laparoscopic Cholecystectomy on the Prognosis of Patients with Gallstones

目的研究腹腔镜胆囊切除术治疗胆结石患者的临床疗效。方法非随机选取2019年10月—2023年8月启东市第二人民医院收治的106例胆结石患者为研究对象,根据不同治疗方法分为对照组和研究组,各53例。对照组行保守治疗,研究组行腹腔镜胆囊切除术。治疗后,采用胆道磁共振检测两组胆囊及胆道结石排尽率,检测两组血清糖类抗原19-9(Carbohydrate Antigen 19-9,CA19-9)、糖类抗原50(Carbohydrate Antigen 50,CA50)和癌胚抗原(Carcinoembryonic Antigen,CEA)水平。对比两组生活质量简表(World Health Organiza-tion Quality of Life-100,WHOQOL-100)评分。结果研究组结石排尽率(92.45%)高于对照组(47.17%),差异有统计学意义(χ^(2)=25.784,P<0.05)。治疗后,研究组CA19-9、CA50、CEA均低于对照组,差异有统计学意义(P均<0.05)。研究组WHOQOL-100各项评分高于对照组,差异有统计学意义(P均<0.05)。结论腹腔镜胆囊切除术在胆结石治疗中具有较高的疗效,能够提高结石排尽率,减轻胆道炎症,提高患者生活质量。

Objective To study the clinical efficacy of laparoscopic cholecystectomy in the treatment of patients with gallstones.Methods A total of 106 patients with gallstones admitted to the Second People's Hospital of Qidong City from October 2019 to August 2023 were non-randomly selected as the research objects.They were randomly divided into a control group and a study group,with 53 cases in each group,according to different treatment modalities.The control group received conservative treatment,while the study group underwent laparoscopic cholecystectomy.After treatment,biliary magnetic resonance imaging was used to detect the clearance rates of gallbladder and biliary stones in two groups,and serum levels of carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 50(CA50),and carcino-embryonic antigen(CEA)were measured in both groups.The World Health Organization Quality of Life-100(WHOQOL-100)scores between two groups were compared.Results The stone clearance rate of the study group(92.45%)was higher than that of the control group(47.17%),and the difference was statistically significant(χ^(2)=25.784,P<0.05).After treatment,CA19-9,CA50 and CEA in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The scores of WHOQOL-100 in the study group were higher than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion Laparoscopic cholecystectomy has a high therapeutic effect in the treatment of gallstones,which can improve the stone clearance rate,reduce biliary inflammation,and improve the quality of life of patients.