甲泼尼龙琥珀酸钠治疗儿童难治性支原体肺炎临床疗效及对炎性因子的影响

Clinical Cfficacy of Methylprednisolone Sodium Succinate in the Treat⁃ment of Refractory Mycoplasma Pneumonia in Children and Its Impact on Inflammatory Factors

目的探究甲泼尼龙琥珀酸钠在儿童难治性支原体肺炎中的作用。方法非随机选择2022年9月—2023年10月南京市高淳人民医院收治的108例支原体肺炎患儿为研究对象,不同治疗方法分两组,各54例。对照组采用阿奇霉素治疗,研究组联用甲泼尼龙琥珀酸钠静脉滴注治疗。对比两组的症状缓解时间、临床疗效、炎性因子及免疫功能。结果研究组的症状缓解时间短于对照组,炎症水平低于对照组,免疫功能优于对照组,差异有统计学意义(P均<0.05)。研究组的总有效率(96.29%)高于对照组(85.19%),差异有统计学意义(χ^(2)=3.967,P<0.05)。结论甲泼尼龙琥珀酸钠治疗儿童难治性支原体肺炎,能够缓解炎症反应,提高免疫力,促进症状缓解,提高临床疗效。

Objective To explore the role of methylprednisolone sodium succinate in children with refractory myco-plasma pneumonia.Methods A total of 108 children with mycoplasma pneumonia treated in Nanjing Gaochun People's Hospital from September 2022 to October 2023 were non-randomly selected as the study objects and divided into two groups with 54 cases each by different treatment modalities.The control group was treated with azithromycin,and the study group was treated with methylprednisolone sodium succinate intravenously.Symptom remission time,clinical efficacy,inflammatory factors and immune function were compared between the two groups.Results The symptom remission time of the study group was shorter than that of the control group,the inflammation level was lower than that of the control group,and the immune function was better than that of the control group,the differences were statistically significant(all P<0.05).The total effective rate of the study group(96.29%)was higher than that of the control group(85.19%),and the difference was statistically significant(χ^(2)=3.967,P<0.05).Conclusion Methylpred-nisolone sodium succinate in the treatment of refractory mycoplasma pneumonia in children can alleviate inflamma-tion,improve immunity,promote symptom relief and improve clinical efficacy.