妊娠期女性铁蛋白与甲状腺激素水平的相关性研究

A Study on the Correlation between Ferritin and Thyroid Hormone Levels in Pregnant Women

目的探究妊娠期女性铁蛋白与甲状腺激素水平之间的相关性。方法选取2021年1—12月齐齐哈尔医学院附属第一医院产检的妊娠期女性300例,分为孕早期组(≤12周末)(n=100)、孕中期组(13~27周末)(n=100)、妊娠晚期组(28~40周末)(n=100),并选取同时间段来本院体检的健康的非孕期女性100例作为对照组。对比四组的血清游离三碘甲腺原氨酸(Free Triiodothyronine,FT3)、游离甲状腺素(Free Thyroxine,FT4)、促甲状腺激素(Thyroid Stimulating Hormone,TSH)和铁蛋白水平。分析妊娠期女性铁蛋白与与甲状腺激素水平之间的相关性。结果孕早期血清TSH、铁蛋白水平均低于正常对照组;妊娠中、晚期血清FT3、FT4、铁蛋白水平降低,差异有统计学意义(P均<0.05)。随着孕周的增长,TSH水平均呈上升趋势,铁蛋白水平呈降低趋势,妊娠早、晚期比较,差异有统计学意义(P均<0.05)。Pearson相关分析结果显示,妊娠晚期组的铁蛋白与FT3、FT4血清甲状腺激素水平存在相关性(P均<0.05),而其他妊娠组及正常对照组与血清甲状腺激素水平无相关性(P均>0.05)。结论随着孕期增加,孕晚期的妊娠期妇女的铁蛋白与FT3、FT4甲状腺激素水平之间存在正相关性,其提示临床密切关注妊娠期孕妇的甲状腺功能异常情况以及铁蛋白水平的变化趋势,以此早期予以患者治疗措施,降低不良妊娠结局发生率。

Objective To explore the correlation between ferritin and thyroid hormone levels in pregnant women.Methods 300 pregnant female patients who underwent prenatal examinations at the First Affiliated Hospital of Qiqi-har Medical College from January to December 2021 were selected and divided into three groups:early pregnancy group(≤12 weekends)(n=100),mid pregnancy group(13-27 weekends)(n=100),and late pregnancy group(28-40 weekends)(n=100).Additionally,100 healthy non pregnant women who came to our hospital for physical examinations during the same period were selected as the control group.Compare the serum levels of free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH),and ferritin among four groups.The correlation between ferri-tin and thyroid hormone levels in pregnant women.Results Serum TSH and ferritin levels in early pregnancy were lower than those in the healthy control group;the levels of serum FT3,FT4,and ferritin decreased significantly in the middle and late stages of pregnancy(all P<0.05).As the gestational age increases,TSH levels show an upward trend;the level of ferritin show a downward trend,and there is a significant difference between early and late pregnancy(both P<0.05).The Pearson correlation analysis results showed that there was a correlation between ferritin and serum thyroid hormone levels of FT3 and FT4 in the late pregnancy group(both P<0.05),while there was no correlation be-tween serum thyroid hormone levels in other pregnancy groups and normal control groups(both P>0.05).Conclusion With the increase of pregnancy,there is a positive correlation between ferritin and FT3,FT4 thyroid hormone levels in pregnant women in the late stage of pregnancy.This suggests that clinical attention should be paid to the abnormal thy-roid function and changes in ferritin levels in pregnant women,in order to provide early treatment measures for pa-tients and reduce the incidence of adverse pregnancy outcomes.