甲氨蝶呤、硫酸羟氯喹联合塞来昔布治疗对类风湿性关节炎患者免疫功能及骨代谢的影响

The Effects of Methotrexate,Hydroxychloroquine Sulfate Combined with Celecoxib Treatment on Immune Function and Bone Metabolism in Pa⁃tients with Rheumatoid Arthritis

目的探究甲氨蝶呤、硫酸羟氯喹联合塞来昔布治疗类风湿性关节炎患者的效果。方法非随机选取2021年1月—2023年10月北京积水潭医院贵州医院收治120例类风湿性关节炎患者为研究对象,按治疗方法分成对照组与研究组,各60例。对照组行甲氨蝶呤、硫酸羟氯喹治疗,研究组行甲氨蝶呤、硫酸羟氯喹联合塞来昔布治疗,对比两组的骨代谢、免疫功能、不良反应发生情况。结果研究组的免疫功能指标和骨代谢水平优于对照组,差异有统计学意义(P均<0.05)。两组的不良反应发生率比较(21.67%vs 11.67%),差异无统计学意义(χ^(2)=1.500,P>0.05)。结论在采用硫酸羟氯喹、甲氨蝶呤治疗类风湿性关节炎患者的前提下,联合应用塞来昔布治疗不但能提高患者的免疫功能,还能调节其骨代谢,具有较高的安全性。

Objective To explore the effect of methotrexate,hydroxychloroquine sulfate combined with celecoxib in the treatment of patients with rheumatoid arthritis.Methods A total of 120 patients with rheumatoid arthritis admitted to Guizhou Hospital of Beijing Jishuitan Hospital from January 2021 to October 2023 were non-randomly selected as the study objects,and were divided into control group and study group by treatment method,with 60 cases in each group.The control group was treated with methotrexate and hydroxychloroquine sulfate,and the study group was treated with methotrexate and hydroxychloroquine sulfate combined with celeoxib.The bone metabolism,immune func-tion and adverse reactions of the two groups were compared.Results The immune function indexes and bone metabo-lism level of the study group were better than those of the control group,and the differences were statistically signifi-cant(both P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(21.67%vs 11.67%)(χ^(2)=1.500,P>0.05).Conclusion Under the premise of using hydroxychloroquine sulfate and methotrexate in the treatment of rheumatoid arthritis patients,the combination of celecoxib can not only improve the immune function of patients,but also regulate their bone metabolism,with high safety.