达格列净片联合二甲双胍片治疗2型糖尿病的临床效果

Clinical Effect of Dapagliflozin Tablets Combined with Metformin Tablets in the Treatment of Type 2 Diabetes Mellitus

目的探讨2型糖尿病(T2DM)患者采用达格列净片联合二甲双胍片治疗的临床效果。方法选取2022年5月至2023年7月我院收治的60例T2DM患者,采用随机数字表法分成观察组和对照组各30例。对照组采用二甲双胍片治疗,观察组采用达格列净片联合二甲双胍片治疗,对两组临床疗效、血糖水平、体质量指数(BMI)、不良反应发生率进行比较。结果观察组治疗总有效率为93.33%,高于对照组的66.67%,差异有统计学意义(P<0.05);治疗后,两组空腹血糖值(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbAlc)水平均下降,且观察组较对照组更低,差异有统计学意义(P<0.05);治疗后,两组BMI降低,且观察组较对照组更低,差异有统计学意义(P<0.05);观察组不良反应发生率为6.67%,稍低于对照组的13.33%,差异无统计学意义(P>0.05)。结论达格列净片联合二甲双胍片应用于T2DM患者治疗中,能够提高临床疗效,改善血糖水平,降低BMI,安全性较高。

Objectives To investigate the clinical effect of Dapagliflozin tabletscombined with Metformin tablets in patients with type 2 diabetes mellitus(T2DM).Methods A total of 60 T2DM patients admitted to our hospital from May 2022 to July 2023 were selectedand divided into observation group and control group randomly,with 30 cases in each group.The control group was treated with Metformin tablets,and the observation group was treated with Dapagliflozin combined with Metformin tablets.The clinical efficacy,blood glucose level,body mass index(BMI),and incidence of adverse reactions were compared between the both groups.Results The total effective rate of the observation group was 93.33%,which was significantly higher than the 66.67%in control group(P<0.05).After treatment,the level of fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),and glycosylated hemoglobin(HbAlc)levels in both groups decreased,and those in the observation group were significantly lower than the control group(P<0.05).After treatment,the BMI of the two groups decreased,and the index in the observation group was significantly lower than the control group(P<0.05).The incidence of adverse reactions in the observation group was 6.67%,which was slightly lower than the 13.33%in control group,and the difference was not statistically significant(P>0.05).Conclusions The combination of Dapagliflozin and Metformin tablets in the treatment of T2DM patients can improve clinical efficacy,improve blood sugar levels,reduce BMI,and have high safety.