罗库溴铵麻醉诱导在胆囊结石患者手术中的应用效果观察

Study on the Anesthetic Effect of Rocuronium Bromide in Patients Undergoing Gallstone Operation under General Anesthesia

目的研究罗库溴铵在胆囊结石患者手术麻醉中的应用效果。方法选取2021年1月至2022年12月我院收治的90例胆囊结石患者为研究对象,均行全麻手术治疗,采用随机数字表法分为对照组和观察组各45例。对照组采用顺式阿曲库铵麻醉诱导,观察组采用罗库溴铵麻醉诱导,对比两组气管插管效果,对比两组麻醉时间及恢复时间,对比两组血流动力学变化,对比两组不良反应发生情况。结果观察组气管插管优良率为97.78%,与对照组的93.33%比较,差异无统计学意义(P>0.05)。观察组麻醉起效时间、手术时间、麻醉时间、术后拔管时间、恢复室停留时间及术中肌松药物追加次数显著低于对照组,麻醉持续时间显著高于对照组,差异有统计学意义(P<0.05)。与T_(0)相比,T_(1)、T_(2)、T_(3)时,两组HR、MAP、SpO_(2)明显降低,差异有统计学意义(P<0.05);但两组间HR、MAP、SpO_(2)比较,差异无统计学意义(P>0.05)。观察组不良反应发生率为4.44%,显著低于对照组的20.00%,差异有统计学意义(P<0.05)。结论全麻胆囊结石手术中采取罗库溴铵进行麻醉诱导可获得更好的肌松效果,利于气管插管成功,并缩短麻醉起效时间、手术时间,延长麻醉持续时间,而且血流动力学稳定,不良反应率低,值得推广。

Objectives To investigate the anesthetic effect of rocuronium bromide in patients undergoing gallstone surgery under general anesthesia.Methods A total of 90 patients with cholecystolithiasis admitted to our hospital from January 2021 to December 2022 were selected as the study objects and underwent general anesthesia surgery.They were divided into control group and observation group by random number table method,with 45 cases in each group.The control group was anesthetized with cisatracurium,while the observation group was anesthetized with rocuronium.The effect of tracheal intubation,anesthesia time and recovery time,hemodynamic changesand the adverse reactions were compared between the two groups.Results The excellent and good rate of tracheal intubation was 97.78%in observation group and 93.33%in control group,with no statistical significance(P>0.05).The effective time of anesthesia,operation time,anesthesia time,postoperative extubation time,recovery room stay time and intraoperative muscle relaxant drug addition times in the observation group were significantly lower than those in the control group,and the duration of anesthesia was significantly higher than that in the control group(P<0.05).Compared with T_(0),HR,MAP and SpO_(2)in the two groups were significantly lower at T_(1),T_(2)and T_(3)(P<0.05).However,there was no statistically significant difference in HR,MAP,and SpO_(2)between the two groups(P>0.05).The incidence of adverse reactions in the observation group was 4.44%,which was significantly lower than the 20%in the control group(P<0.05).Conclusions The use of rocuronium bromide for anesthesia induction in gallstone surgery under general anesthesia can achieve better muscle relaxation effect,facilitatethe success of tracheal intubation,shorten the onset time of anesthesia,operation time,prolong the duration of anesthesia,and have stable hemodynamics and low adverse reaction rate,which is worthy of promotion.