视网膜高反射点数量与糖尿病性黄斑水肿患者房水炎症细胞因子水平的相关性

Correlation of number of retinal hyperreflective foci with aqueous humor inflammatory cytokines levels in patients with diabetic macular edema

目的 探讨视网膜高反射点(HF)数量与糖尿病性黄斑水肿(DME)患者房水炎症细胞因子水平的相关性。方法 选取25例DME患者(34只眼)作为研究对象,检测患者房水炎症细胞因子[血管内皮生长因子(VEGF)、转化生长因子β1(TGF-β1)、白细胞介素(IL)-6、IL-17A、单核细胞趋化蛋白1(MCP1)、细胞间黏附分子(ICAM)]水平。采用光学相干断层扫描测量黄斑中心凹厚度(CMT)、黄斑总体积(TMV)、黄斑中心凹体积(CMV),计数HF数量。采用Pearson或Spearman相关分析法分析DME患者HF数量、CMT、TMV、CMV与房水炎症细胞因子水平的相关性。结果 DME患者的HF数量与房水IL-6、MCP1、ICAM水平呈正相关,TMV与房水TGF-β1、MCP1、ICAM水平呈正相关(P<0.05)。结论 DME患者视网膜HF数量与房水IL-6、MCP1、ICAM水平相关,HF可能是眼内炎症的影像标志物。

Objective To investigate the correlation between number of retinal hyperreflective foci(HF)and aqueous humor inflammatory cytokines levels in patients with diabetic macular edema(DME).Methods A total of 25 DME patients(34 eyes)were selected as the research subjects.The levels of aqueous humor inflammatory cytokines with respect to vascular endothelial growth factor(VEGF),transforming growth factorβ1(TGF‐β1),interleukin(IL)‐6,IL‐17A,monocyte chemoattractant protein 1(MCP1),intercellular adhesion molecule(ICAM)were detected in patients.Central macular thickness(CMT),total macular volume(TMV),and central macular volume(CMV)were measured by employing the optical coherence tomography,and number of HF was calculated.The Pearson or Spearman correlation analysis method was used to analyze the correlation of HF number,CMT,TMV,CMV with aqueous humor inflammatory cytokines levels in DME patients.Results HF number positively correlated with aqueous humor IL‐6,MCP1,and ICAM levels,and TMV positively correlated with aqueous humor TGF‐β1,MCP1,and ICAM levels(P<0.05).Conclusion HF number correlates with aqueous humor IL‐6,MCP1,and ICAM levels in DME patients,and HF may be regarded as imaging marker of intraocular inflammations.