血清白细胞介素-17、胱抑素C水平对急性脑梗死患者溶栓治疗预后的预测价值

Prognostic Value of Serum Interleukin-17 and Cystatin C Levels in Patients with Acute Cerebral Infarction after Thrombolytic Therapy

目的:探讨血清白细胞介素(IL)-17、胱抑素C(CysC)水平对急性脑梗死(ACI)患者溶栓治疗预后的预测价值.方法:选取2021年11月至2022年11月在本院接受溶栓治疗的70例ACI患者作为研究对象.采用改良Rankin量表(mRS)评估患者预后,根据患者mRS得分情况,将其分别纳入预后不良组(n=31)和预后良好组(n=39).采集两组患者临床病例资料;检测患者的血清IL-17、CysC水平.比较不同预后情况的ACI患者临床资料以及血清IL-17、CysC水平,分析血清IL-17、CysC水平对患者预后不良风险的预测价值.结果:70例行溶栓治疗ACI患者中,31例预后不良,占比为44.29%(31/70).预后不良组患者血清IL-17水平高于预后良好组,CysC水平低于预后良好组,差异均有统计学意义(P<0.05);两组患者其他临床资料比较,差异无统计学意义(P>0.05).Logistic回归分析结果显示,血清IL-17高表达、CysC低表达,均是导致ACI患者溶栓治疗预后不良的独立危险因素(P<0.05).结论:血清IL-17高表达、CysC低表达与ACI患者溶栓治疗后预后不良有一定关系,对其预后评估具有重要临床价值.

Objective:To investigate the predictive value of serum interleukin(IL)-17 and cystatin C(CysC)levels in the prognosis of thrombolytic therapy in patients with acute cerebral infarction(ACI).Methods:A total of 70 patients with ACI who received thrombolytic therapy in our hospital from November 2021 to November 2022 were selected as the study subjects.The modified Rankin scale(mRS)was used to evaluate the prognosis of the patients,and they were included in poor prognosis group(n=31)and good prognosis group(n=39)according to the mRS scores of the patients.The clinical case data of the two groups of patients were collected.The serum levels of IL-17 and CysC were measured.The clinical data and the serum levels of IL-17 and CysC of ACI patients with different prognostic conditions were compared,and the value of serum IL-17 and CysC levels in assessing the risk of poor prognosis of patients was analyzed.Results:Among the 70 patients who underwent thrombolysis for ACI,31 had poor prognosis,accounting for 44.29%(31/70).The serum IL-17 level in the poor prognosis group was higher than that in the good prognosis group,and the CysC level was lower than that in the good prognosis group,and the differences were statistically significant(P<0.05),and there was no significant difference in other clinical data between the two groups(P>0.05).Logistic regression analysis showed that high serum IL-17 expression and low CysC expression were independent risk factors for poor prognosis of thrombolytic therapy in ACI patients(P<0.05).Conclusion:High serum IL-17 expression and low CysC expression are related to the poor prognosis of ACI patients after thrombolytic therapy,and have important clinical value in the evaluation of their prognosis.