基于共轭微孔聚合物构建电化学传感器灵敏检测肾上腺素

Electrochemical sensor based on conjugated microporous polymer for sensitive detection of epinephrine

通过Sonogashira-Hagihara偶联法制备了一种新型的还原石墨烯基共轭微孔聚合物(CMP-rGO)材料。采用扫描电子显微镜(SEM),透射电子显微镜(TEM),傅里叶变换红外光谱仪(FT-IR)和X射线光电子能谱(XPS)对CMP-rGO的形貌和结构进行表征;利用电化学阻抗法(EIS)和循环伏安法(CV)研究了CMP-rGO材料的电化学性质,并将其应用于肾上腺素(EP)电化学传感器的构建。结果表明,CMP-rGO修饰电极展示出优异的导电性和电催化活性。在优化条件下,EP的氧化电流与其浓度在0.08~80μmol/L之间呈良好的线性关系,检出限为6.741 nmol/L。基于CMP-rGO材料制备的电化学传感器可用于临床疾病诊断。

A novel reduced graphene-based conjugated microporous polymer(CMP-rCO)material was prepared by Sonogashira-Hagihara coupling method.The morphology and structure of CMP-rCO were characterized by scanning electron microscopy(SEM),transmission electron microscopy(TEM),Fourier transform infrared spectroscopy(FT-IR),and X-ray photoelectron spectroscopy(XPS).The electrochemical properties of CMP-rCO material were researched by electrochemical impedance spectroscopy(EIS)and cyclic voltammetry(CV).And the prepared materials were applied to the construction of epinephrine(EP)electrochemical sensors.The results showed the CMP-rGO modified electrode exhibited good electrical conductivity and electrocatalytic activity.Under the optimum conditions,the oxidation current of EP showed a good linear relationship with its concentration in the range of 0.08-80μmol/L,with a detection limit of 6.741 nmol/L.Therefore,electrochemical sensors based on CMP-rGO can be applied to clinical disease diagnosis.