还阳参化学成分与药理作用研究进展及其质量标志物预测分析

Research progress on chemical constituents and pharmacological effects of Crepis crocea and prediction analysis of its quality marker

还阳参为山西特色的中药材,主要用于治疗咳嗽、气喘等疾病。现代药理研究表明,还阳参具有止咳、平喘、抗炎、降糖等药理作用,其药效物质主要包含有机酸类、多糖类、萜类、苯丙素类等化学成分。为进一步探讨其在预防和治疗人体疾病方面发挥的功效,本文拟对还阳参化学成分、现代药理研究进行综述,并依据中药质量标志物(Q-Marker)理论从植物亲缘学、药材功效和化学成分三个方面对还阳参的Q-Marker进行分析与讨论,结果表明绿原酸、咖啡酸等有机酸类及还阳参酯素Ⅰ等萜类、还阳参多糖等多糖类等成分可作为还阳参的主要Q-Marker,为还阳参质量评价体系的规范与完善提供参考。

Crepis crocea is a unique traditional Chinese medicine in Shanxi Province,mainly used to treat diseases such as cough and asthma.Modern pharmacological research has shown that Crepis crocea has pharmacological effects such as relieving cough,relieving asthma,resisting inflammation and lowering blood sugar.Its active substances mainly include organic acids,polysaccharides,terpenes,phenylpropanoids,and other chemical components.In order to further explore its functional role in the prevention and treatment of human diseases,this paper intends to review the chemical constituents and modern pharmacological research of Crepis crocea.Based on the quality marker(Q-marker)theory of traditional Chinese medicine,the Q-marker of Crepis crocea are analyzed and discussed from three aspects:plant kinship,medicinal efficacy and chemical constituents.The results show that organic acids such as chlorogenic acid and caffeic acid,terpenoids such as esterinⅠ,polysaccharides and other polysaccharides could be used as the main Q-marker of Crepis crocea,providing reference for the standardization and improvement of the quality evaluation system of Crepis crocea.