加味生肌玉红膏促进下肢创伤后慢性难愈性创面修复研究

Research on Modified Shengji Yuhong Ointment in promoting the rehabilitation of chronic refractory wounds after lower limb trauma

目的研究加味生肌玉红膏治疗下肢创伤后慢性难愈合创面的临床疗效。方法选取2022年1月至2023年10月就诊于毕节市中医医院骨伤科诊断为下肢创伤后慢性难愈合创面的患者60例,以投掷硬币方法分为研究组(30例)和对照组(30例)。对照组患者采用常规外科清创换药联合重组人表皮生长因子凝胶治疗,研究组患者采用常规外科清创换药联合加味生肌玉红膏治疗。比较两组创面细菌培养情况,创面压疮愈合评价量表,治疗1、4周C反应蛋白(CRP),红细胞沉降率(ESR),创面面积减小率等指标。结果两组患者治疗情况比较,研究组细菌培养情况、炎性指标、创面减少率均明显优于对照组,差异有统计学意义(P<0.05)。结论采用加味生肌玉红膏治疗下肢创伤后慢性难愈合创面,能加速创面愈合,减少修复时间,值得临床推广应用。

Objective To investigate the clinical efficacy of Modified Shengji Yuhong Ointment in the treatment of chronic refractory wounds after lower limb trauma.Methods A total of 60 patients who were diagnosed as chronic refractory wounds after lower limb trauma admitted to the Department of Orthopedics of Bijie Traditional Chinese Medicine Hospital from January 2022 to October 2023 were selected and divided into the study group(n=30)and the control group(n=30)according to the coin throwing method.Patients in the control group were treated with conventional surgical debridement and dressing change combined with recombinant human epidermal growth factor gel,while those in the study group were treated with conventional surgical debridement and dressing change combined with Modified Shengji Yuhong Ointment.Indices such as the wound bacterial culture,wound pressure ulcer scale for healing score,and C-reactive protein(CRP),erythrocyte sedimentation rate(ESR)and wound area reduction rate of the two groups at 1 week and 4 weeks after treatment were compared and evaluated.Results The treatment outcomes of the two groups of people were compared,and the bacterial culture,inflammatory indices and wound reduction rate of the study group were obviously superior to those of the control group,with statistically significant differences(P<0.05).Conclusion Modified Shengji Yuhong Ointment is used to treat chronic refractory wounds after lower limb trauma,which can accelerate wound healing and reduce rehabilitation time,and is worthy of clinical promotion and application.