芪精丹兰汤加味联合间歇性限食疗法对代谢综合征患者的疗效观察

Effect observation of modified Qijing Danlan Decoction combined with intermittent food restriction therapy on patients with metabolic syndrome

目的探讨芪精丹兰汤加味联合间歇性限食疗法在代谢综合征患者中的应用效果。方法选择2022年10月至2023年10月北京中医药大学厦门医院门诊治疗的代谢综合征患者100例,根据随机数表法分组,对照组脱落3例,研究组脱落2例。对照组47例采用常规西医治疗,研究组48例在对照组基础上采用芪精丹兰汤加味联合间歇性限食疗法,两组均持续治疗12周。观察两组治疗前、治疗12周后的人体肥胖指标、糖、脂代谢、血压、维生素D水平及不良反应发生情况。结果两组治疗后的腰围、身体质量指数(BMI)、体脂肪及体脂率均低于治疗前,但对照组治疗前后比较,差异无统计学意义(P>0.05),研究组治疗前后比较,差异有统计学意义(P<0.05);研究组治疗后的腰围、BMI、体脂肪及体脂率均低于对照组,差异有统计学意义(P<0.05);两组治疗后的空腹血糖、空腹胰岛素及胰岛素抵抗指数、空腹总胆固醇、甘油三酯、收缩压及舒张压水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组治疗后的25-羟维生素D3高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论芪精丹兰汤加味联合间歇性限食疗法能够改善代谢综合征患者肥胖情况、糖代谢与脂代谢水平,并可调节患者血压,提高其维生素D水平,不会增加不良反应。

Objective To explore the application effect of Qijing Danlan Decoction combined with intermittent food restriction therapy on patients with metabolic syndrome.Methods A total of 100 patients with metabolic syndrome in the outpatient department of Xiamen Hospital of Beijing University of Chinese Medicine from October 2022 to October 2023 were selected and divided into two groups using a random number table method.3 patients were excluded from the control group and 2 patients were excluded from the study group.47 patients in the control group were treated with routine western medicine,while 48 patients in the study group were treated with Qijing Danlan Decoction combined with intermittent food restriction therapy on the basis of the control group.Both groups were treated continuously for 12 weeks.Obesity index,glucose metabolism index,lipid metabolism index,blood pressure,vitamin D level and adverse reactions of the two groups were observed before and after treatment for 12 weeks.Results The waist circumference,body mass index(BMI),body fat and body fat rate of the two groups after treatment were lower than those before treatment,but there was no statistically significant difference(P>0.05)between the control group and the study group before and after treatment,and the differences were statistically significant(P<0.05).After treatment,the waist circumference,BMI,body fat and body fat rate in the study group were lower than those in the control group,with statistically significant difference(P<0.05).The levels of fasting blood glucose,fasting insulin and insulin resistance index,fasting total cholesterol,triglyceride,systolic blood pressure and diastolic blood pressure in the two groups after treatment were lower than those before treatment,with statistically significant differences(P<0.05).The levels of 25-hydroxyvitamin D3 in the two groups after treatment were higher than that before treatment,and that level of the study group was higher than that of the control group,with a statistically significant difference(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Qijing Danlan Decoction combined with intermittent food restriction therapy can improve the obesity,glucose metabolism and lipid metabolism of patients with metabolic syndrome,and can adjust their blood pressure and increase their vitamin D level without increasing adverse reactions.