鞘内泵入吗啡联合羟考酮缓释片口服治疗中重度癌痛的临床效果研究

Clinical efficacy of intrathecal pumping of morphine combined with oral administration of hydroxycodone sustained-release tablets in the treatment of moderate and severe cancer pain

目的分析中重度癌痛患者采用鞘内泵入吗啡结合羟考酮缓释片口服治疗的效果。方法选取2020年6月至2023年6月泉州市第一医院收治的70例中重度癌痛患者,采用随机数表法将其均分为两组,每组各35例。对照组采用羟考酮缓释片口服治疗,观察组在对照组基础上联合鞘内泵入吗啡治疗。比较疼痛评分、炎症指标、不良反应发生率及生活质量评分。结果治疗后观察组疼痛评分较对照组低,差异有统计学意义(P<0.05)。治疗后观察组红细胞沉降率、C反应蛋白、白细胞介素6水平均较对照组低,差异有统计学意义(P<0.05)。观察组不良反应总发生率较对照组低,差异无统计学意义(P>0.05)。观察组治疗后生活质量评分较对照组高,差异有统计学意义(P<0.05)。结论鞘内泵入吗啡联合羟考酮缓释片口服应用在中重度癌痛治疗中,可缓解患者疼痛感,降低其机体炎症水平,提升其生活质量,临床上可借鉴及推广。

Objective To analyze the efficacy of intrathecal pumping of morphine combined with oral administration of hydroxycodone sustained-release tablets in the treatment of patients with moderate to severe cancer pain.Methods A total of 70 patients with moderate and severe cancer pain were selected from the patients admitted to the Quanzhou First Hospital,Fujian from June 2020 to June 2023,and were randomly divided into two groups using a random number table method,with 35 cases in each group.The control group was treated with hydroxycodone sustained-release tablets orally,and the observation group was treated with a combination of intrathecal pumping of morphine on the basis of the control group.The pain score,inflammation index,adverse reaction rate and quality of life score were compared between two groups.Results After treatment,the pain score in the observation group was lower than that in the control group,with the difference was statistically significant(P<0.05).After treatment,the levels of erythrocyte sedimentation rate,C-reactive protein,and interleukin-6 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was not statistically significant(P>0.05).The quality of life score of the observation group after treatment was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Intrathecal pumping of morphine combined with oral administration of hydroxycodone sustained-release tablets in the treatment of moderate to severe cancer pain can alleviate patient pain,reduce their level of inflammation,and improve their quality of life.It can be used for reference and promotion in clinical practice.