维生素D联合肺康复训练在慢性阻塞性肺疾病急性加重期患者中的应用效果分析

Analysis on Application Effect of Vitamin D Combined with Pulmonary Rehabilitation Training in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的:分析维生素D联合肺康复训练在慢性阻塞性肺疾病急性加重期(AECOPD)患者中的应用效果。方法:选取2021年1月—2022年12月上海市虹口区北外滩街道社区卫生服务中心收治的60例AECOPD患者作为研究对象,随机分为观察组和对照组,各30例。对照组给予维生素D滴剂治疗,观察组在对照组基础上进行肺康复训练。比较两组治疗效果。结果:治疗后,两组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1占预计值的百分比、FEV1/FVC均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组症状严重程度、呼吸困难评分低于治疗前,且观察组低于对照组,两组6 min步行距离大于治疗前,且观察组大于对照组,差异有统计学意义(P<0.05)。治疗后,两组C反应蛋白、降钙素原、白细胞计数、中性粒细胞水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:维生素D联合肺康复训练在AECOPD患者中的应用效果显著,可促进患者肺功能恢复,缓解临床症状,提高运动耐力、自我管理能力,加快炎症消退。

Objective:To analyze the application effect of vitamin D combined with pulmonary rehabilitation training in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:Sixty patients with AECOPD admitted to Shanghai Hongkou District Beiwaitan Sub-district Community Health Service Center from January 2021 to December 2022 were selected as the study subjects.They were randomly divided into control group and observation group,with 30 cases in each group.The control group received vitamin D drops treatment,and the observation group received pulmonary rehabilitation training on the basis of the control group.The treatment effects were compared between the two groups.Results:After treatment,the forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),percentage of FEV1 to the predicted value,and FEV1/FVC in the two groups were higher than those before treatment,and these indexes in the observation group were higher than those in the control group,with a statistically significant difference(P<0.05).After treatment,the severity of symptoms and the dyspnea scores in the two groups were lower than those before treatment,and these indexes in the observation group were lower than those in the control group,while the 6-min walking distance in the two groups was longer than that before treatment,and this index in the observation group was longer than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of C-reactive protein,procalcitonin,white blood cell count and neutrophil in the two groups were lower than those before treatment,and these indexes in the observation group were lower than those in the control group,with a statistically significant difference(P<0.05).Conclusion:The application of vitamin D combined with pulmonary rehabilitation training in patients with AECOPD has a significant effect,and can promote the recovery of lung function,alleviate clinical symptoms,improve exercise endurance and self-management ability,and accelerate the disappearance of inflammation.