不同时间点液体复苏治疗对非重症急性胰腺炎患者的疗效探讨

Exploring the Efficacy of Different Simultaneous Fluid Resuscitation Therapy in Patients with Non-severe Acute Pancreatitis

目的 探究不同时间点液体复苏治疗对非重症急性胰腺炎患者的疗效。方法 回顾性选取2020年5月—2023年5月于烟台业达医院接受治疗的80例非重症急性胰腺炎患者的临床资料,根据患者液体复苏治疗时间的不同分为对照组和观察组,每组40例。对照组患者腹痛开始12 h后内接受液体复苏治疗,观察组患者腹痛开始8 h内接受液体复苏治疗,对比分析两组治疗效果差异。结果 观察组患者生命体征恢复时间、禁食/禁饮时间及住院时间短于对照组,差异有统计学意义(P均<0.05)。观察组患者多器官衰竭发生率(2.50%)低于对照组(15.00%),差异有统计学意义(P<0.05)。两组患者的介入治疗、全身炎症反应、接受机械通气发生率比较,差异无统计学意义(P均>0.05)。治疗后两组患者的血肌酐、尿素氮水平均升高,淀粉酶、C反应蛋白水平均降低,观察组指标水平优于对照组,差异有统计学意义(P均<0.05)。结论 非重症急性胰腺炎患者于腹痛开始8 h内接受液体复苏治疗,对于促进患者症状快速缓解、改善其临床转归和外周血生化指标的价值显著。

Objective To explore the efficacy of fluid resuscitation at different time points in patients with non-severe acute pancreatitis.Methods Clinical data of 80 patients with non-severe acute pancreatitis treated in Yantai Yeda Hospital from May 2020 to May 2023 were retrospectively selected.According to the different time of fluid resuscita-tion,the patients were divided into control group and observation group,with 40 cases in each group.Patients in the control group received fluid resuscitation within 12 hours after the onset of abdominal pain,and patients in the obser-vation group received fluid resuscitation within 8 hours after the onset of abdominal pain.The differences in treatment effects between the two groups were compared and analyzed.Results The recovery time of vital signs,fasting/no drink-ing time and hospitalization time of patients in observation group were shorter than those in control group,and the dif-ferences were statistically significant(all P<0.05).The incidence of multiple organ failure in the observation group(2.50%)was lower than that in the control group(15.00%),and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of interventional therapy,systemic inflammatory response and me-chanical ventilation between the two groups(all P>0.05).After treatment,the levels of serum creatinine and urea nitro-gen were increased,and the levels of amylase and C-reactive protein were decreased in both groups,the indexes level of the observation group were better than those of the control group,and the differences were statistically significant(all P<0.05).Conclusion Patients with non-severe acute pancreatitis receiving fluid resuscitation within 8 hours of the onset of abdominal pain have a significant value in promoting rapid relief of symptoms,improving clinical outcomes and peripheral blood biochemical indicators.