冠心病合并糖尿病患者治疗中运用他汀类药物的效果分析

Analysis of the Effect of Statins in the Treatment of Coronary Heart Dis⁃ease Patients with Diabetes

目的 分析冠状动脉粥样硬化性心脏病(简称冠心病)合并糖尿病运用他汀类药物治疗的临床价值。方法 方便选取2022年9月—2023年9月临沂市人民医院收治的92例冠心病合并糖尿病患者为研究对象,依据奇偶数法分为参考组和探究组,每组46例,参考组予以基础治疗,探究组辅以他汀类药物治疗。比较两组患者血糖、血脂指标水平,血管内皮功能及不良反应发生情况。结果 治疗后,探究组空腹血糖、餐后2 h血糖均低于参考组,差异有统计学意义(P均<0.05)。治疗后,两组患者血脂指标较治疗前均好转,且探究组总胆固醇、甘油三酯均低于参考组,差异有统计学意义(P均<0.05)。治疗前,两组患者血管内皮功能比较,差异无统计学意义(P>0.05)。治疗后,探究组血管内皮功能优于参考组,差异有统计学意义(P<0.05)。探究组不良反应总发生率为4.35%,低于参考组的19.57%,差异有统计学意义(χ^(2)=5.059,P=0.024)。结论 他汀类药物对血脂的调节效果好,能规避不良反应,预防疾病复发,并能提高斑块稳定性,恢复血管内皮功能,具有临床研究价值。

Objective To analyze the value of statin therapy in patients with coronary atherosclerotic heart disease(CHD)and diabetes.Methods A total of 92 patients with coronary heart disease and diabetes mellitus treated in Linyi People's Hospital from September 2022 to September 2023 were conveniently selected as the study objects,and were divided into reference group and inquiry group according to odd-even method,with 46 cases in each group.The ref-erence group was given basic treatment,and the inquiry group was supplemented with statins.The levels of blood glucose,blood lipids,vascular endothelial function and the occurrence of adverse reactions were compared between the two groups.Results After treatment,fasting blood glucose and 2 h postprandial blood glucose in the inquiry group were lower than those in the reference group,the differences were statistically significant(both P<0.05).After treat-ment,blood lipid indexes in both groups were improved compared with those before treatment,and total cholesterol and triglyceride in the inquiry group were lower than those in the reference group,the differences were statistically sig-nificant(all P<0.05).Before treatment,there was no significant difference in vascular endothelial function between the two groups(P>0.05).After treatment,vascular endothelial function in the inquiry group was better than that in the ref-erence group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the inquiry group was 4.35%,which was lower than that in the reference group(19.57%),the difference was statistically significant(χ^(2)=5.059,P=0.024).Conclusion Statins have good regulating effect on blood lipids,can avoid adverse re-actions,prevent disease recurrence,improve plaque stability,and restore vascular endothelial function,which has clinical research value.