急性心衰合并高血压危象急救中乌拉地尔与硝酸甘油效果对比

Comparison of the Effects of Urapidil and Nitroglycerin in Emergency Treatment of Acute Heart Failure Complicated with Hypertensive Crisis

目的探究乌拉地尔与硝酸甘油在急性心力衰竭(简称心衰)合并高血压危象急救中的应用效果。方法回顾性选取2020年10月—2023年10月安溪县医院收治的100例急性心衰合并高血压危象患者的临床资料,根据不同急救治疗方案分组,采用硝酸甘油治疗的50例患者为药物1组,采用乌拉地尔治疗的50例患者为药物2组。观察两组患者的血压值、心功能指标及药物不良反应。结果治疗前,两组患者的血压值和心功能指标对比,差异无统计学意义(P均>0.05)。治疗后,两组患者的舒张压及收缩压水平降低,但组间差异无统计学意义(P均>0.05);两组患者左心收缩末期内径(Left Ventricular End-systolic Dimension,LVESD)、左室舒张末期内径(Left Ventricular End-diastolic Diameter,LVEDD)降低,心输出血量(Cardiac Output,CO)、每搏输出量(Stroke Volume,SV)及左心室射血分数(Left Ventricular Ejection Fractions,LVEF)升高,且药物2组LVESD、LVEDD均低于药物1组,CO、SV、LVEF均高于药物1组,差异有统计学意义(P均<0.05)。药物2组的药物不良反应总发生率为4.00%,低于药物1组的18.00%,差异有统计学意义(χ^(2)=5.005,P<0.05)。结论乌拉地尔与硝酸甘油在急性心衰合并高血压危象急救中降压疗效一致,乌拉地尔心功能改善效果更佳,且不良反应较少。

Objective To explore the application effect of urapidil and nitroglycerin in the emergency treatment of acute heart failure complicated with hypertension crisis.Methods The clinical data of 100 patients with acute heart failure complicated with hypertensive crisis admitted to Anxi County Hospital from October 2020 to October 2023 were retrospectively selected.According to different emergency treatment regimens,50 patients treated with nitroglycerin were divided into drug group 1,and 50 patients treated with urapidil were divided into drug group 2.The blood pressure,cardiac function indexes and adverse drug reactions of the two groups were observed.Results Before treatment,there was no significant difference in blood pressure and cardiac function between the two groups(both P>0.05).After treatment,the levels of diastolic blood pressure and systolic blood pressure in the two groups were decreased,but there was no significant difference between the two groups(both P>0.05).Left ventricular end-systolic dimension(LVESD)and left ventricular end-diastolic diameter(LVEDD)were decreased in the two groups,cardiac output(CO),stroke volume(SV)and left ventricular ejection fractions(LVEF)were increased,and LVESD and LVEDD in drug group 2 were both lower than those in drug group 1,CO,SV and LVEF were all higher than those in drug group 1,the differences were statistically significant(all P<0.05).The total incidence of adverse drug reactions in drug group 2 was 4.00%,which was lower than that in drug group 1(18.00%),the difference was statistically significant(P<0.05).Conclusion Uralidil and nitroglycerin have the same antihypertensive effect in emergency treatment of acute heart failure complicated with hypertensive crisis.Uralidil has a better effect on improving heart function and fewer adverse reactions.