新生儿呼吸窘迫综合征治疗中猪肺磷脂注射液多方位给药的应用效果研究

Study on the Effect of Multifaceted Administration of Poractant Alaf Injection in The Treatment of Neonatal Respiratory Distress Syndrome

目的探究治疗新生儿呼吸窘迫综合征(Neonatal Respiratory Distress Syndrome,NRDS)中选择猪肺磷脂注射液多方位给药的应用效果。方法简单随机选取2021年6月—2023年6月莆田市儿童医院收治的60例NRDS患儿为研究对象,使用信封法将患儿分为对照组和研究组,每组30例。对照组患儿接受气管内滴注猪肺磷脂注射液治疗,研究组患儿通过猪肺磷脂注射液多方位给药的方式进行治疗。比较不同治疗措施下两组患儿临床疗效、血氧水平、并发症发生率。结果两组患儿临床疗效对比,观察组患儿总有效率(96.67%)较对照组更高,差异有统计学意义(χ^(2)=4.043,P<0.05)。治疗前,两组患儿血氧饱和度(Blood Oxygen Saturation,SaO_(2))、动脉血氧分压(Arterial Partial Pressure of Oxyge,PaO_(2))、动脉血二氧化碳分压(Arterial Carbon Dioxide Partial Pressure,PaCO_(2))、二氧化碳总量(Total Carbon Dioxide,TCO_(2))对比,差异无统计学意义(P均>0.05)。治疗24 h后,两组患儿动脉血气分析指标对比,研究组患儿SaO_(2)水平(93.65±4.15)%、PaO_(2)水平(85.63±2.41)mmHg均高于对照组,PaCO_(2)水平(43.65±2.24)mmHg、TCO_(2)水平(35.41±2.81)mmHg均低于对照组,差异有统计学意义(t=2.471、2.674、3.370,2.897,P均<0.05)。两组患儿并发症总发生率对比,差异无统计学意义(P>0.05)。结论猪肺磷脂注射液治疗新生儿窘迫综合征患儿时选择多方位给药,疗效优于气管内滴注,可改善动脉血气指标,有效控制并发症发生风险。

Objective To explore the application effect of multi-directional administration of Poractant Alfa injection in the treatment of Neonatal Respiratory Distress Syndrome(NRDS).Methods A total of 60 children with NRDS admitted to Putian Children's Hospital from June 2021 to June 2023 were simple randomly selected as the research objects.The children were divided into control group and study group by envelope method,with 30 cases in each group.The children in the control group were treated with intratracheal instillation of poractant alfa injection,and the children in the study group were treated with multi-directional administration of poractant alfa injection.The clinical efficacy,blood oxygen level and complication rate of the two groups were compared under different treatment measures.Results The total effective rate of the observation group(96.67%)was higher than that of the control group,the difference was statistically significant(χ^(2)=4.043,P<0.05).Before treatment,there was no significant difference in blood oxygen saturation(SaO_(2)),arterial partial pressure of oxygen(PaO_(2)),arterial carbon dioxide partial pressure(PaCO_(2)),and total carbon dioxide(TCO_(2))between the two groups(all P>0.05).After 24 hous of treatment,the arterial blood gas analysis indexes of the two groups were compared,and the SaO_(2) level was(93.65±4.15)%and PaO_(2) level was(85.63±2.41)mmHg in the study group,which were higher than those in the control group.PaCO_(2) level was(43.65±2.24)mmHg and TCO_(2) level was(35.41±2.81)mmHg,which were lower than those of control group,the differences were statistically significant(t=2.471,2.674,3.370,2.897,all P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion Poractant alfa injection is more effective than intratracheal instillation in the treatment of neonatal distress syndrome in children.It can improve arterial blood gas index and effectively control the risk of complications.