维生素B_(12)联合四联疗法治疗幽门螺杆菌阳性慢性萎缩性胃炎的临床效果

Clinical Effect of Vitamin B_(12) Combined with Quadruple Therapy in Treatment of Helicobacter Pylori Positive Chronic Atrophic Gastritis

目的:分析幽门螺杆菌阳性慢性萎缩性胃炎患者采用维生素B_(12)联合四联疗法治疗的临床效果。方法:选取2021年1月—2023年1月泰兴市人民医院收治的幽门螺杆菌阳性慢性萎缩性胃炎患者80例作为研究对象,随机分为观察组与对照组,各40例。对照组患者给予四联疗法治疗,观察组患者在对照组治疗基础上采用维生素B_(12)治疗。对比两组治疗效果。结果:治疗后,观察组患者临床症状改善时间明显短于对照组,Hp清除率高于对照组,并发症发生率、用药不良反应发生率、复发率均低于对照组(P<0.05)。观察组患者胃泌素、胃动素水平优于对照组,治疗总有效率高于对照组(P<0.05)。结论:幽门螺杆菌阳性慢性萎缩性胃炎患者采用维生素B_(12)联合四联疗法进行治疗,可获得较好的临床治疗效果及用药安全性,能够尽早改善患者临床症状,清除体内幽门螺杆菌,减少并发症的发生,促进患者消化功能恢复。

Objective:To analyze the clinical effect of vitamin B_(12) combined with quadruple therapy in patients with Helicobacter pylori positive chronic atrophic gastritis.Methods:Eighty patients with Helicobacter pylori positive chronic atrophic gastritis who received treatment in Taixing People's Hospital from January 2021 to January 2023 were selected as the study subjects.They were randomly divided into an observation group and a control group,with 40 cases in each group.The control group received quadruple therapy,while the observation group received vitamin B_(12) treatment on the basis of the control group.The treatment effects of the two groups were compared.Results:After treatment,the clinical symptom improvement time in the observation group was significantly shorter than that in the control group,the Helicobacter pylori clearance rate in the observation group was higher than that in the control group,and the incidence of complications,incidence of adverse drug reactions,and recurrence rate in the observation group were all lower than those in the control group(P<0.05).The gastrin and motilin levels in the observation group were better than those in the control group,and the total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).Conclusion:The treatment of vitamin B_(12) combined with quadruple therapy in patients with Helicobacter pylori positive chronic atrophic gastritis can achieve good clinical treatment effects and medication safety.It can improve the clinical symptoms of patients as soon as possible,eliminate Helicobacter pylori in the body,reduce the occurrence of complications,and promote the recovery of digestive function of patients.