特布他林、阿奇霉素联合布地奈德治疗儿童急性支气管炎的临床效果

Clinical Effect of Terbutaline,Azithromycin Combined with Budesonide in Treatment of Acute Bronchitis in Children

目的:探讨特布他林、阿奇霉素联合布地奈德治疗儿童急性支气管炎的临床效果。方法:选取2022年5月—2024年2月石河子市城中医院收治的急性支气管炎患儿106例作为研究对象,随机分为二联组、三联组,各53例。二联组采取二联疗法(特布他林联合阿奇霉素)治疗,三联组采取三联疗法(特布他林、阿奇霉素、布地奈德)治疗。比较两组炎性指标、免疫功能、肺功能。结果:治疗前,两组降钙素原(PCT)、C反应蛋白(CRP)及白细胞介素-6(IL-6)水平对比,差异无统计学意义(P>0.05);治疗后,两组PCT、CRP、IL-6水平下降,且三联组低于二联组(P<0.05)。治疗前,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平对比,差异无统计学意义(P>0.05);治疗后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平升高,且三联组高于二联组(P<0.05)。治疗前,两组呼气峰值流速(PEF)、第1秒用力呼气容积(FEV1)对比,差异无统计学意义(P>0.05);治疗后,两组PEF、FEV1升高,且三联组高于二联组(P<0.05)。结论:急性支气管炎患儿接受特布他林、阿奇霉素、布地奈德三种药物联合治疗,能显著减轻机体炎症,增强免疫功能和肺功能,值得临床推广使用。

Objective:To explore the clinical effect of terbutaline,azithromycin combined with budesonide in treatment of children with acute bronchitis.Methods:A total of 106 children with acute bronchitis admitted to Urban Hospital in Shihezi City from May 2022 to February 2024 were selected as the study subjects.They were randomly divided into double group and triple group,with 53 cases in each group.The double group received double therapy(terbutaline plus azithromycin),and the triple group received triple therapy(terbutaline,azithromycin,budesonide).Inflammatory indicator,immune function and lung function were compared between the two groups.Results:Before treatment,there was no significant difference in the levels of procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)between the two groups(P>0.05).After treatment,the levels of PCT,CRP,IL-6 decreased in the two groups,and the levels in the triple group were lower than those in the double group(P<0.05).Before treatment,there was no significant difference in the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)between the two groups(P>0.05).After treatment,the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)increased in the two groups,and the levels in the triple group were higher than those in the double group(P<0.05).Before treatment,there was no significant difference in peak expiratory flow rate(PEF)and forced expiratory volume in 1 second(FEV1)between the two groups(P>0.05).After treatment,PEF and FEV1 increased in the two groups,and those indexes in the triple group were higher than those in the double group(P<0.05).Conclusion:The combined treatment of terbutaline,azithromycin and budesonide in children with acute bronchitis can significantly relieve inflammation,and enhance immune function and lung function,which is worthy of clinical popularization.