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DDX58基因多态性与乙型肝炎病毒感染慢性化关联的研究

Association between DDX58 gene polymorphism and chronic HBV infection
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摘要 目的探究维甲酸诱导基因I(DDX58)中的单核苷酸多态性位点(SNPs)是否与乙型肝炎病毒(HBV)感染慢性化有关。方法2009年9月-2010年3月间,选取张家港市20个村的48417人进行健康检查并定期随访,于2020年11月共纳入842例基线乙肝表面抗原(HBsAg)阳性患者为研究对象,其中无症状感染者674例,慢性乙型肝炎(CHB)患者168例。对2个单核苷酸多态性位点(DDX58 rs9695310、rs10738889)进行基因分型,采用t检验、χ^(2)检验、多因素logistic回归等多种统计学方法,探讨其与HBV感染慢性化的关系。结果rs9695310基因多态性与HBV感染慢性化相关(P=0.004)。与无症状感染者相比,rs9695310的突变C等位基因与患者慢性化显著相关(显性模型:OR=1.74,95%CI:1.18~2.54)。同时,rs9695310、性别、年龄、血小板、白球比例及总胆固醇是HBV感染慢性化的独立预测因子(P均<0.05)。ROC曲线显示,以上6个独立因素都能够较好地将HBV感染慢性化感染者同无症状感染者进行区分(AUC=0.738)。结论位于DDX58上的rs9695310的突变C等位基因与中国汉族人群HBV感染慢性化具有相关性,可作为HBV感染转归的预测指标。 Objective DExD/H⁃box helicase 58(DDX58)plays an important role in human innate immunity and may affect the prognosis of hepatitis B virus(HBV)infection.The aim of this study was to investigate the association of single nucleotide polymorphic sites(SNPs)in the RIG⁃I gene with HBV infection chronicity.Methods A total of 48417 people from 20 villages in Zhangjiagang were selected for health examination and regular follow⁃up from September 2009 to March 2010.A total of 842 baseline hepatitis B surface antigen(HBsAg)positive patients were included in this study in November 2020;674 were asymptomatic and 168 were chronic hepatitis B(CHB).Two SNPs(DDX58 rs9695310,rs10738889)were genotyped to explore their relationship with HBV infection chronicity.t⁃test,χ^(2)⁃test and multivariate logistic regression were applied to analyze the relationship of these SNPs with HBV infection chronicity.Results rs9695310 gene polymorphism was associated with HBV infection chronicity(P=0.004).Compared with asymptomatic carriers,patients carrying the mutated allele rs9695310⁃C were more likely to become chronic(dominant model:OR=1.74,95%CI:1.18-2.54).Mutations in the rs9695310 gene were risk factors for chronic HBV infection;rs9695310,gender,age,platelets,A/G,and total cholesterol were independent predictors of HBV infection chronicity.The ROC curve analysis showed the above six independent factors could effectively distinguish chronic HBV infection from asymptomatic infection(AUC=0.738).Conclusion DDX58 rs9695310 was associated with chronic HBV infection in Chinese Han population and could serve as a predictive indicator for the outcome of HBV infection.
作者 刘宇畅 姚轶男 沈艳 季燕 黄鹏 李敏 姚海萍 丁玲云 LIU Yuchang;YAO Yinan;SHEN Yan;JI Yan;HUANG Peng;LI Min;YAO Haiping;DING Lingyun(Department of Infectious Disease Control,Zhangjiagang Center for Disease Control and Prevention,Suzhou,Jiangsu 215600,China;Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Key Laboratory of Infectious Diseases,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China)
出处 《热带医学杂志》 CAS 2024年第7期1040-1043,1052,共5页 Journal of Tropical Medicine
基金 江苏省张家港市医学重点学科(张卫科教[2016]7号) 张家港市卫生青年科技项目(ZJGQNKJ202020)。
关键词 DDX58 rs9695310 基因多态性 乙型肝炎 DDX58 rs9695310 Gene polymorphism Hepatitis B
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