阿司匹林预防先兆子痫的作用机制及药物相关基因多态性研究进展

Research progress on mechanism of aspirin in preventing preeclampsia and drug related gene polymorphism

先兆子痫是一种常见的妊娠期高血压疾病,严重危害母婴健康。早期应用低剂量阿司匹林在可有效预防先兆子痫,并可以有效降低发生溶血肝功能异常血小板减少综合征、胎盘早剥及胎儿窘迫等并发症的概率。近年来,随着研究的不断深入,较多实验证据表明基因多态性与阿司匹林抵抗存在相关性,由于部分患者存在基因多态性,从而达不到预期治疗效果。本文就先兆子痫高危孕妇阿司匹林精准用药的研究进展进行综述,以指导阿司匹林在预防先兆子痫高危孕妇这类特殊人群的用药,改善妊娠结局。

Preeclampsia is a common hypertensive disorder of pregnancy,which seriously endangers the health of mothers and infants.The early application of low-dose aspirin can effectively prevent preeclampsia,and effectively reduce the probability of hemolysis,elevated liver function and low platelet count syndrome,placental abruption,and fetal distress.In recent years,with the deepening of research,more experimental evidences show that there is a correlation between gene polymorphisms and aspirin resistance.Because some patients have gene polymorphisms,the expected therapeutic effect cannot be achieved.This paper reviewed the research progress of precision medication of aspirin in high-risk pregnant women with preeclampsia,in order to guide the medication of aspirin in special groups such as pregnant women with preeclampsia and improve pregnancy outcomes.