新型抗抑郁药托鲁地文拉法辛

A novel antidepressant toludesvenlafaxine

新型抗抑郁药托鲁地文拉法辛,又名安舒法辛,是我国自主研发的一种三重单胺类再摄取抑制剂,可通过与5-羟色胺转运体、去甲肾上腺素转运体和多巴胺转运体结合,阻断以上3种神经递质的再摄取而发挥抗抑郁作用。该药起效较快,能够显著改善抑郁障碍患者的心境低落、快感缺失、动力下降等症状,缓解伴发的焦虑症状,且治疗过程中不易导致性功能障碍等不良反应。临床在使用该药时应注意从小剂量开始,同时对患者进行转躁风险的评估和管理。由于该药可作用于多巴胺通路,临床还需关注治疗中是否会引起患者的精神病性症状。

The new antidepressant toludesvenlafaxine,also known as ansofaxine,is a triple monoaminergic reuptake inhibitor independently developed in China.It can play an antidepressant effects by blocking the reuptake of the three neurotransmitters by combining with the serotonin transporter,noradrenaline,and dopamine transporter.Toludesvenlafaxine has a rapid effect,which can significantly improve the low mood,anhedonia,lack of motivation and other symptoms of patients with depressive disorders,relieve the associated anxiety symptoms,and is not easy to lead to sexual dysfunction and other adverse reactions in the treatment process.While using toludesvenlafaxine,clinicians should start titration with a low dose and assess the risk of mania during the course of treatment,and pay attention to whether the drug could cause psychotic symptoms,since it acts on the dopamine pathway.