虎杖清脉饮治疗下肢小血管病早期热郁毒聚证临床观察

The clinical effect of Huzhang Qingmai decoction in the treatment of early heat depression and toxin accumulation syndrome in lower limb small vessel disease

目的:观察虎杖清脉饮治疗下肢小血管病(LESAD)早期热郁毒聚证的临床治疗效果和安全性。方法:选取70例LESAD早期热郁毒聚证患者随机分为试验组和对照组各35例,两组患者均给予西医常规治疗,在此基础上,试验组给予虎杖清脉饮颗粒治疗,对照组给予虎杖清脉饮安慰剂颗粒治疗,3个月后比较两组临床疗效,治疗前后症状体征积分、中医证候积分,治疗前后脂代谢、糖代谢、炎症因子水平变化、安全性及不良反应情况。结果:试验组总有效率94.11%高于对照组63.33%(P<0.05);治疗后试验组症状、体征积分及中医证候积分较对照组显著降低(P<0.05);实验室指标中,治疗后试验组脂代谢、糖代谢、炎症因子水平均较对照组改善(P<0.05)。结论:虎杖清脉饮治疗LESAD早期热郁毒聚证患者临床疗效显著,可明显改善患者临床症状,减少动脉粥样硬化的诱发因素。

Objective:To observe the clinical efficacy and safety of Huzhang Qingmai decoction in the treatment of early heat toxicity syndrome of lower extremity small arterial disease(LESAD).Methods:A total of 70 patients were randomly divided into experimental group and control group,35 patients in each group.Both groups of patients were treated with conventional Western medicine.On this basis,the experimental group was treated with Huzhang Qingmai decoction,while the control group was treated with Huzhang Qingmai decoction placebo granules.After 3 months of treatment,the clinical efficacy of the two groups was evaluated.The symptom and sign scores,traditional Chinese medicine syndrome scores,lipid metabolism,glucose metabolism,inflammatory factor levels before and after treatment,and safety were compared between the two groups.Results:The total effective rate of experimental group was 94.11%higher than that of control group(63.33%).In laboratory indexes,lipid metabolism,glucose metabolism,blood rheology and inflammatory factors in experimental group were improved compared with control group after treatment(P<0.05).Conclusion:Huzhang Qingmai decoction has significant clinical effect in treating LESAD patients with early heat-stagnation and toxic-accumulation syndrome,which can significantly improve clinical symptoms and reduce the predisposing factors of atherosclerosis.