益气活血开窍方联合西医常规治疗对脑梗死恢复期患者神经功能、血液流变学和血清炎症因子的影响

Effects of Yiqi Huoxue Kaiqiao decoction combined with conventional western medicine on neurological function,hemorheology and serum inflammatory factors in patients with cerebral infarction during convalescence

目的:探讨脑梗死恢复期患者在常规西医基础上予以益气活血开窍方的治疗效果。方法:将脑梗死恢复期患者103例随机分为对照组51例与观察组52例,分别予以常规西医治疗、益气活血开窍方联合西医治疗,两组均治疗8周。对两组美国国立卫生院卒中量表(NIHSS)、Fugl-Meyer运动功能量表(FMA)、改良Barthel指数(MBI)进行评估,对比两组血液流变学[全血黏度(高切)、血浆黏度、纤维蛋白原水平]和血清炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)];并比较两组疗效和不良反应。结果:与对照组比较,观察组总有效率更高(86.54%与70.59%,P<0.05)。治疗后,与对照组比较,观察组NIHSS评分更低,FMA评分和MBI评分更高(P<0.05),且观察组全血黏度(高切)、血浆黏度、Fib水平和血清IL-6、TNF-α水平更低(P<0.05)。两组不良反应比较无统计学差异(P>0.05)。结论:脑梗死恢复期患者在常规西医基础上予以益气活血开窍方治疗有较好疗效,能够调节血液流变学,减轻炎症,促进神经功能恢复和肢体运动功能的提高。

Objective:To investigate the therapeutic effect of Yiqi Huoxue Kaiqiao decoction on patients with cerebral infarction at convalescent stage on the basis of conventional western medicine.Methods:A total of 103 cerebral infarction patients at recovery stage were divided into control group(51 cases)and observation group(52 cases)randomly.They were treated with conventional western medicine,Yiqi Huoxue Kaiqiao decoction combined with western medicine respectively.Both groups were treated for 8 weeks.The National Institutes of Health Stroke Scale(NIHSS),Fugl-Meyer motor function scale(FMA)and modified Barthel index(MBI)were evaluated in the two groups.The hemorheology[whole blood viscosity(high shear),plasma viscosity,fibrinogen level]and serum inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]were compared between the two groups.The efficacy and adverse reactions of the two groups were compared.Results:The observation group’s total effective rate of was higher(86.54%vs 70.59%,P<0.05)comparing with the control group.After treatment,compared with the control group,the observation group’s NIHSS score was lower,the FMA score and MBI score were higher(P<0.05),and the whole blood viscosity(high shear),plasma viscosity,Fib level and serum IL-6 and TNF-αlevels in the observation group were lower(P<0.05).The adverse reactions between the two groups shows no significant difference(P>0.05).Conclusion:Yiqi Huoxue Kaiqiao decoction on the basis of conventional western medicine has a good effect on patients with cerebral infarction in convalescence,which can regulate hemorheology,reduce inflammation,promote the recovery of neurological function and the improvement of limb motor function.