血小板参数NF-κB IL-6水平检测与肝硬化患者合并上消化道出血病情及转归的关联性研究

Correlation Study of Platelet Parameters NF-κB IL-6 Levels with Disease Severity and Prognosis in Patients with Cirrhosis Complicated by Upper Gastrointestinal Bleeding

目的:分析血小板参数、血清核因子-κB(NF-κB)、白介素-6(IL-6)水平与肝硬化患者合并上消化道出血病情及转归的关联性。方法:将2021年1月至2024年1月于本院就诊的155例肝硬化合并上消化道出血患者为研究对象,依据入院治疗前的失血量将其分为轻度组(n=70)和中重度组(n=85)。另外依据其病情转归情况分为预后良好组(n=122)与预后不良组(n=33),测定所有研究对象的血小板参数[血小板计数(PLT)、血小板平均体积(MPV)、血小板比容(PCT)、血小板分布宽度(PDW)]、血清NF-κB、IL-6水平,以Spearman秩相关性分析血小板参数、NF-κB、IL-6水平与肝硬化合并上消化道出血患者病情及转归的关联性。结果:中重度组的PLT、MPV、PCT、PDW、血清NF-κB、IL-6水平高于轻度组(P<0.05);预后不良组的PLT、MPV、PCT、PDW、血清NF-κB、IL-6水平高于预后良好组(P<0.05)。Spearman秩相关性分析显示,PLT、MPV、PCT、PDW、血清NF-κB、IL-6水平与肝硬化合并上消化道出血患者的病情严重程度均呈正相关(r=0.226,0.311,0.387,0.311,0.351,0.386,P<0.05)。结论:血小板参数、NF-κB、IL-6水平与肝硬化合并上消化道出血患者的病情及转归密切相关,早期检测血清上述指标可为临床评估病情及转归提供一定的参考依据。

Objective:To analyze the correlation between platelet parameters,serum nuclear factor-κB(NF-κB),interleukin-6(IL-6)levels,and the disease severity and prognosis in patients with cirrhosis complicated by upper gastrointestinal bleeding(UGIB).Methods:A total of 155 patients with cirrhosis complicated by UGIB,treated at our hospital from January 2021 to January 2024,were included in the study.Based on the amount of blood loss before admission,they were divided into a mild group(n=70)and a moderate to severe group(n=85).Additionally,based on the prognosis,they were categorized into a good prognosis group(n=122)and a poor prognosis group(n=33).Platelet parameters[platelet count(PLT),mean platelet volume(MPV),plateletcrit(PCT),platelet distribution width(PDW)],serum NF-κB,and IL-6 levels were measured in all patients.Spearman rank correlation analysis was used to evaluate the relationship between these parameters and the severity and prognosis of cirrhosis complicated by UGIB.Results:The PLT,MPV,PCT,PDW,serum NF-κB,and IL-6 levels in the moderate to severe group were significantly higher than those in the mild group(P<0.05).Similarly,these parameters were higher in the poor prognosis group compared to the good prognosis group(P<0.05).Spearman rank correlation analysis indicated a positive correlation between PLT,MPV,PCT,PDW,serum NF-κB,IL-6 levels,and the severity of cirrhosis complicated by UGIB(r=0.226,0.311,0.387,0.311,0.351,0.386;P<0.05).Conclusion:Platelet parameters,NF-κB,and IL-6 levels are closely related to the severity and prognosis of patients with cirrhosis complicated by UGIB.Early detection of these serum indicators can provide a reference for clinical assessment of disease severity and prognosis.