氯胺酮:从麻醉镇痛药到抗抑郁药

Ketamine: from narcotic analgesics to antidepressants

氯胺酮诞生距今已有六十多年的历史。氯胺酮因其镇痛效果好、呼吸循环影响小等优点广泛应用于临床麻醉。然而,氯胺酮的快速且持久抗抑郁作用,使其在抗抑郁治疗领域也展现出广阔的应用前景。本文概述了氯胺酮的药理学特性及作为麻醉镇痛药物的临床应用,重点综述了氯胺酮及其代谢产物的抗抑郁作用及进展。

Ketamine compound was firstly synthesized for more than 60 years.It is widely used in clinical anesthesia due to its potent analgesic effect and lower deleterious impacts on circulatory and respiratory functions.Very recently,its rapid and long-lasting antidepressant effect attracted increasing attentions in the topic field.We therefore reviewed the pharmacological properties of ketamine,its clinical application as a narcotic analgesic,and antidepressant effect of its metabolites.