3D打印可降解聚乳酸共聚物多孔支架的制备与性能评价

Preparation and properties of 3D printed degradable porous scaffolds based on copolymer of polylactic acid

为了开发具有高生物亲和性和优异修复效果的骨组织工程材料,合成了含有聚乙二醇亲水链段的聚乳酸共聚物(PELA),将共聚物与生物活性成分纳米羟基磷灰石共混,通过3D打印熔融沉积成型法制备了一系列结构完整、孔隙均匀的多孔支架,考察了组分含量和孔隙率对支架压缩强度的影响。实验结果表明,改善共聚物的亲水性可提升材料的生物亲和性,对共聚物材料性质和生物毒性的研究证明合成的含有聚乙二醇亲水链段的共聚物PELA适合作为可降解支架的基质材料。

To fabricate bone tissue engineering materials with high bio-affinity and superior repair capability,polylactic acid copolymer with polyethylene glycol hydrophilic segment(PELA)was synthesized.On this basis,the copolymer was blended with bioactive hydroxyapatite nanoparticles.The composite materials were fabricated into scaffolds with integrated architecture and uniform pores by fused deposition modeling 3D printing.A comparative analysis was conducted to assess the impact of component ratio and porosity on the compressive strength of these scaffolds.The experimental results indicate that better hydrophilicity of PELA can lead to better bio-affinity of the material.Upon examination of the properties and biotoxicity,the PELA is determined to be a suitable matrix material for degradable scaffolds.