老年冠心病人群脂溶性维生素水平分布及与病情程度的相关性

Distribution of Lipid Soluble Vitamin Levels in Elderly Patients with Coronary Heart Disease and Their Correlation with The Severity of Disease

目的:探讨老年冠心病人群脂溶性维生素水平分布及与病情程度的相关性。方法:选取2022年1月—2024年2月在我院治疗的老年冠心病患者82例作为观察组,同时选取同期因胸部不适行CAG检查排除冠心病的患者30例作为对照组,观察两组血清维生素D、E、A、K1水平,同时比较观察组不同病变程度、疾病类型患者间差异。结果:观察组维生素D为(22.41±6.40)nmol/L,明显低于对照组(P<0.05),而维生素E、维生素K1和维生素A分别为(14.25±2.22)μg/mL、(1.44±0.35)ng/mL、(72.25±13.35)ng/mL,明显高于对照组(P<0.05)。观察组重度病变患者维生素D为(15.84±6.11)nmol/L,明显低于轻度和中度病变患者(P<0.05),而维生素E、维生素K1和维生素A分别为(17.47±2.00)μg/mL、(1.80±0.24)ng/m L、(79.80±11.87)ng/mL,明显高于轻度和中度病变患者(P<0.05)。观察组急性心肌梗死患者维生素D为(20.07±5.06)nmol/L,明显低于不稳定性心绞痛患者(P<0.05),而维生素E、维生素K1、维生素A分别为(17.47±2.00)μg/mL、(1.80±0.24)ng/mL、(79.80±11.87)ng/mL,明显高于不稳定性心绞痛患者(P<0.05)。维生素D与病情严重程度呈负相关(r=-0.362,P<0.05),维生素E、维生素K1、维生素A与病情严重程度呈正相关(r=0.800、0.786、0.236,P<0.05)。结论:老年冠心病人群维生素D水平降低,而维生素E、K1、A水平升高,其中维生素D与病情严重程度存在负相关,而维生素E、K1、A病情严重程度存在正相关关系。

【Objective】To explore the distribution of lipid soluble vitamin levels in elderly patients with coronary heart disease and their correlation with the severity of the condition.【Method】Totally 82 elderly patients with coronary heart disease who were treated in our hospital from January 2022 to February 2024 were selected as the observation group.At the same time,30 patients with coronary heart disease excluded from CAG examination due to chest discomfort during the same period were selected as the control group.The serum levels of vitamin D,E,A,and K1 were observed in the two groups,and the differences between patients with different degrees and types of lesions were compared.【Result】The vitamin D in the observation group was(22.41±6.40)nmol/L,which was significantly lower than the control group(P<0.05),while vitamin E,vitamin K1,and vitamin A were(14.25±2.22),(1.44±0.35),and(72.25±13.35)ng/mL,respectively,which was significantly higher than the control group(P<0.05).The vitamin D of the observation group with severe lesions was(15.84±6.11)nmol/L,which was significantly lower than that of mild and moderate lesions(P<0.05),while vitamin E,vitamin K1,and vitamin A were(17.47±2.00)μg/mL,(1.80±0.24)ng/mL,and(79.80±11.87)ng/mL,respectively,which was significantly higher than those of mild and moderate lesions(P<0.05).The vitamin D levels in the observation group of patients with acute myocardial infarction were(20.07±5.06)nmol/L,significantly lower than those in the un-stable angina patients(P<0.05),while vitamin E,vitamin K1,and vitamin A levels were(17.47±2.00)μg/mL,(1.80±0.24)ng/mL,and(79.80±11.87)ng/mL,respectively,which was significantly higher than those in the un-stable angina patients(P<0.05).Vitamin D was negatively correlated with severity(r=-0.362,P<0.05),while vitamin E,vitamin K1,and vitamin A were positively correlated with severity(r=0.800,0.786,and 0.236,μg/L<0.05).【Conclusion】The levels of vitamin D in elderly patients with coronary heart disease decrease,while the levels of vitamin E,K1,and A increase.Among them,vitamin D is negatively correlated with the severity of the disease,while vitamin E,K1,and A are positively correlated with the severity of the disease.