高乙型肝炎病毒前基因组RNA的乙型肝炎病毒感染者临床特征分析

Clinical characteristics analysis of hepatitis B virus infected individuals with high hepatitis B virus pregenomic RNA

目的分析高乙型肝炎病毒(hepatitis B virus,HBV)前基因组RNA(pregenomic RNA,pgRNA)人群的临床特征,进一步探索pgRNA在慢性乙型病毒性肝炎(乙肝)患者管理中的价值。方法纳入2020年12月1日-2022年4月1日于四川大学华西医院感染性疾病中心肝炎门诊治疗随访的长期使用核苷类似物治疗的慢性乙肝患者,分析总结高pgRNA慢性乙肝患者的临床特征。结果共纳入107例患者。男性患者占比66.4%,平均年龄为44.02岁。高pgRNA组与低pgRNA组的性别、年龄、天冬氨酸转氨酶、丙氨酸转氨酶、γ-谷氨酰转移酶、HBV表面抗原、HBV e抗原≥0.1 U/mL的患者比例、HBV DNA、甲胎蛋白差异均无统计学意义(P>0.05)。高pgRNA组HBV表面抗原<100 U/mL的患者比例低于低pgRNA组(4.4%vs.22.6%,P<0.05)。结论高pgRNA的慢性乙肝患者HBV表面抗原≥100 U/mL的比例更高。

Objective To analyze the clinical characteristics of individuals with high hepatitis B virus(HBV)pregenomic RNA(pgRNA),and further explore the value of pgRNA in the management of patients with chronic hepatitis B.Methods From December 1st,2020 to April 1st,2022,chronic hepatitis B patients who had been treated with nucleotide analogues for a long time and followed up in the Hepatitis Clinic of the Center of Infectious Diseases,West China Hospital,Sichuan University were included,and the clinical characteristics of chronic hepatitis B patients with high pgRNA were analyzed and summarized.Results A total of 107 patients were included.Male patients accounted for 66.4%,with an average age of 44.02 years.There were no statistically significant differences in gender,age,aspartate transaminase,alanine transaminase,γ-glutamyl transferase,HBV surface antigen,proportion of patients with HBV e antigen≥0.1 U/mL,HBV DNA,and alpha fetoprotein between the high and low pgRNA groups(P>0.05).The proportion of patients with HBV surface antigen<100 U/mL in the high pgRNA group was lower than that in the low pgRNA group(4.4%vs.22.6%,P<0.05).Conclusion The proportion of chronic hepatitis B patients with high pgRNA whose HBV surface antigen≥100 U/mL is higher.