胎球蛋白B与冠状动脉疾病的研究进展

Research progress of fetuin B and coronary artery disease

冠状动脉疾病(coronary artery disease,CAD)是一种主要由动脉粥样硬化引起的心血管疾病,其涉及脂质代谢、炎症反应、内皮功能障碍等多种病理生理机制。胎球蛋白B是一种由肝脏分泌的糖蛋白,能够参与细胞炎症、血管钙化及脂质代谢等多个过程,与CAD的发病密切相关。该文就胎球蛋白B和CAD的关系及发生发展机制进行了综述,以期为CAD的预防和诊治提供新的选择和方法。

Coronary artery disease(CAD)is a cardiovascular disease mainly caused by atherosclerosis,which involves a variety of pathophysiological mechanisms such as lipid metabolism,inflammatory response,and endothelial dysfunction.Fetuin B is a glycoprotein secreted by the liver,which can participate in many processes such as cell inflammation,vascular calcification,and lipid metabolism,and is closely related to the pathogenesis of CAD.This article reviews the relationship between fetuin B and CAD and the mechanism of its occurrence and development,in order to provide new choices and methods for the prevention,diagnosis,and treatment of CAD.