还原偶联有机反应研究进展

Research Progress in Reductive Coupling Organic Reactions

在过去的数十年这里,偶联反应一直被视作有机化学合成领域内的重要合成策略之一,尤其是在近几年,还原偶联反应更是成为众多知名科学家广泛关注的热点。过渡金属区的众多金属元素都具有作为还原偶联反应催化剂的潜力,这其中不仅包括钯、铱等昂贵的金属催化剂,镍、铜、铁等廉价易得的催化剂也大量地被应用于还原偶联反应领域。镍催化的还原偶联反应相较于其他传统偶联方法,其化学合成路径被极大地简化,大多采用一锅合成法,减少了复杂繁琐中间体的使用,这也使得其经济效益有着显著的提高,符合现代化学的绿色发展理念。

In the past few decades,coupling reactions have been recognized as one of the important synthesis strategies in the field of organic chemistry synthesis,especially in recent years,reductive coupling reactions have become a hot topic of widespread concern among many well-known scientists.The numerous metal elements in the transition metal region have the potential to serve as catalysts for reductive coupling reactions,including not only expensive metal catalysts such as palladium and iridium,but also inexpensive and readily available catalysts such as nickel,copper,and iron,which are widely used in the field of reductive coupling reactions.Compared with other traditional coupling methods,the reductive coupling reaction catalyzed by nickel has greatly simplified its chemical synthesis path,mostly using a one pot synthesis method,reducing the use of complex and cumbersome intermediates,which also significantly improves its economic benefits and conforms to the green development concept of modern chemistry.