深静脉血栓形成相关生物标志物的研究进展

Research progress of biomarkers related to deep vein thrombosis

目的 总结深静脉血栓形成(deep venous thrombosis,DVT)新型生物标志物及其研究进展,为DVT的预防、诊断和治疗提供新思路。方法 查阅近5年来国内外有关DVT生物标志物的文献并进行整理与归纳。结果 根据文献检索结果,共整理出血清微小核糖核酸、纤维蛋白单体、中性粒细胞捕捉网、E-选择素等多种常见DVT生物标志物,但大都未被应用于临床DVT管理。目前,临床中对DVT的确诊需要D-二聚体检测阳性与影像学检查阳性相结合,没有单一的生物标志物可以诊断DVT。结论 生物标志物在DVT诊疗中价值显著,但敏感度与特异度需优化。因此,寻找更具诊断价值的生物标志物是未来研究的方向之一;同时,也可以考虑充分地结合多种现有生物标志物,改善对DVT的诊断效能。

Objective To summarize the new biomarkers of deep venous thrombosis(DVT)and their research progress,so as to provide new ideas for the prevention,diagnosis and treatment of DVT.Method The literature about biomarkers of DVT in recent 5 years was reviewed and summarized.Results According to the results of literature review,a variety of common DVT biomarkers such as serum microrna,fibrin monomer,neutrophil capture net,and Eselectin were sorted out,but most of them had not been used in clinical DVT management.At present,the clinical diagnosis of DVT required the combination of positive D-dimer test and positive imaging examination,and there was no single biomarker for the diagnosis of DVT.Conclusions Biomarkers are valuable in the diagnosis and treatment of DVT,but their sensitivity and specificity need to be optimized.Therefore,finding biomarkers with more diagnostic value is one of the future directions.At the same time,we also can consider fully combined with a variety of existing biomarkers,to improve the efficiency to the diagnosis of DVT.