血管平滑肌细胞表型转化对动脉粥样硬化作用的研究进展

Research progress of phenotype transformation of vascular smooth muscle cells on atherosclerosis

动脉粥样硬化(AS)是一种血管壁内的慢性炎症疾病,是冠心病、脑梗死及外周血管疾病的主要病理基础。作为粥样斑块中最主要的细胞类型,血管平滑肌细胞(VSMCs)在AS进程中起重要作用。本文阐述了血管平滑肌细胞表型转化对动脉粥样硬化作用研究的最新进展,为AS的治疗与研究提供可靠的理论依据。

Atherosclerosis(AS)is a chronic inflammatory disease in the blood vessel wall,which is the main pathological basis of coronary heart disease,cerebral infarction and peripheral vascular disease.As the leading cell type in atherosclerotic plaques,vascular smooth muscle cells(VSMCs)play an important role in AS progression.This paper will explain the latest progress of the transformation of VSMCs on atherosclerosis,and provide a reliable theoretical basis for the treatment and research of AS.